NRCAM and ANK2

Number of citations of the paper that reports this interaction (PMID 11449000)
20

Data Source:
HPRD (in vitro)

		NRCAM	ANK2
Gene Name		neuronal cell adhesion molecule	ankyrin 2, neuronal
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuron Projection Axon Initial Segment Synapse	Intracellular Cytosol Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Structural Constituent Of Cytoskeleton Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding ATPase Binding
	Biological Process	Angiogenesis Neuron Migration Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Protein Localization Single Organismal Cell-cell Adhesion Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Axon Guidance Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Protein Targeting To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Membrane Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity
Pathways		Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions NrCAM interactions	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Coffee consumption ( 21876539) Femoral neck bone geometry and menarche (age at onset) ( 23593202)	Blood trace element (Cu levels) ( 23720494) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		8 interactors: ANK2 CNTN2 HSPA12A LNX1 MACF1 MAGI3 NFASC PTPRB	12 interactors: DNAJB1 EPB42 KIAA0368 L1CAM NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53
Entrez ID		4897	287
HPRD ID		07207	00110
Ensembl ID		ENSG00000091129	ENSG00000145362
Uniprot IDs		B7Z670 Q14CA1 Q92823	Q01484
PDB IDs		1UEN 1UEY	4D8O
Enriched GO Terms of Interacting Partners?		Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Paranodal Junction Assembly Myelination Axon Ensheathment Neuron Maturation Myelin Assembly Membrane Organization Axon Guidance Anatomical Structure Formation Involved In Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Of Protein Localization To Juxtaparanode Region Of Axon Protein Localization To T-tubule Anatomical Structure Morphogenesis Axonogenesis Cellular Protein Localization Protein Localization To M-band Positive Regulation Of Adenosine Receptor Signaling Pathway T-tubule Organization Cell-cell Junction Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Endoplasmic Reticulum Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Clustering Of Voltage-gated Potassium Channels Generation Of Neurons Cell Maturation Protein Localization To Plasma Membrane Regulation Of Axonogenesis Protein Targeting To Membrane Neurogenesis Cell Morphogenesis Involved In Differentiation Membrane Depolarization During SA Node Cell Action Potential Cell Junction Assembly SA Node Cell Action Potential Neuron Projection Development Cell-cell Junction Organization Cell Projection Morphogenesis Clustering Of Voltage-gated Sodium Channels Regulation Of Axon Diameter Protein Localization Cell Part Morphogenesis Plasma Membrane Organization Posttranslational Protein Targeting To Membrane Regulation Of Cardiac Muscle Cell Membrane Potential Establishment Of Protein Localization To Membrane Cerebral Cortex GABAergic Interneuron Migration Atrial Cardiac Muscle Cell Action Potential	Regulation Of Cellular Component Organization Regulation Of Cell Growth Membrane Organization Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Morphogenesis Neurogenesis Anatomical Structure Development Regulation Of Intracellular Signal Transduction Axonogenesis Cell Morphogenesis Cell Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Component Assembly Cell Projection Organization Regulation Of Growth Developmental Process Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Morphogenesis System Development Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Size Regulation Of Axon Extension Neuron Projection Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Neuron Projection Development Axon Guidance Neuron Development Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Endomembrane System Organization Regulation Of Signal Transduction B Cell Differentiation Negative Regulation Of Helicase Activity Protein Localization To M-band Positive Regulation Of Cell Growth Regulation Of Cell Projection Organization Protein Import Into Nucleus Protein Localization Protein Metabolic Process Nuclear Import Neuron Differentiation
Tagcloud ?		affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Difference) ?		affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Intersection) ?