MT2A and ADAMTS4

Number of citations of the paper that reports this interaction (PMID 16099106)
5

Data Source:
HPRD (two hybrid)

		MT2A	ADAMTS4
Gene Name		metallothionein 2A	ADAM metallopeptidase with thrombospondin type 1 motif, 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding Drug Binding Zinc Ion Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Cellular Copper Ion Homeostasis Cytokine-mediated Signaling Pathway Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Zinc Ion	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ADAMTS4 ASS1 BARD1 CXorf40A DHODH ECT2 JMJD1C PAXIP1 PRKD1 RCHY1 SHBG SPINK7 USP25	11 interactors: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		4502	9507
HPRD ID		08863	04853
Ensembl ID
Uniprot IDs		P02795	O75173
PDB IDs		1MHU 2MHU	2RJP 3B2Z
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Argininosuccinate Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Primary Spermatocyte Growth Cellular Response To Stress Positive Regulation Of Histone Modification Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Protein Kinase D Signaling Negative Regulation Of MRNA 3'-end Processing Cellular Response To Amine Stimulus Response To Mycotoxin Positive Regulation Of Histone Deacetylase Activity 'de Novo' UMP Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Modification Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Ionizing Radiation Regulation Of Metabolic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Deacetylase Activity Positive Regulation Of Cell Death 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Response To Purine-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Aspartate Metabolic Process Arginine Biosynthetic Process Protein K6-linked Ubiquitination Cellular Response To Laminar Fluid Shear Stress Cellular Response To Oleic Acid Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Chorion Development Positive Regulation Of Endothelial Cell Chemotaxis Cellular Response To Oxidative Stress Anatomical Structure Development Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Regulation Of Nucleocytoplasmic Transport Diaphragm Development	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Inflammatory Response Pathogenesis Regulation Of Proteolysis Defense Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Platelet Degranulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Methanol Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Nerve Growth Factor Production Response To Triglyceride Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Response To Inorganic Substance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Secretion By Cell Cell Adhesion Negative Regulation Of Cellular Metabolic Process Response To Chromate Cellular Response To Erythropoietin Nerve Growth Factor Processing Calcium-independent Cell-matrix Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Skeletal System Development Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Serine-type Endopeptidase Activity Male Germ-line Stem Cell Asymmetric Division Secretion Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Negative Regulation Of Serine-type Peptidase Activity
Tagcloud ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover
Tagcloud (Difference) ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover
Tagcloud (Intersection) ?