MT2A and BARD1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MT2A	BARD1
Gene Name		metallothionein 2A	BRCA1 associated RING domain 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus Cytoplasm BRCA1-BARD1 Complex Intracellular Membrane-bounded Organelle BRCA1-A Complex
	Molecular Function	Protein Binding Drug Binding Zinc Ion Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cellular Copper Ion Homeostasis Cytokine-mediated Signaling Pathway Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Zinc Ion	Tissue Homeostasis DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175)
Protein-Protein Interactions		13 interactors: ADAMTS4 ASS1 BARD1 CXorf40A DHODH ECT2 JMJD1C PAXIP1 PRKD1 RCHY1 SHBG SPINK7 USP25	107 interactors: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 BCCIP BCL3 BRCA1 BRD7 BRIP1 CAP1 CASC1 CCDC136 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CRIPAK CSTF1 DCC DDX39B EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AFX HAP1 HIST2H2AC HNRNPC HNRNPLL HSPA14 IDI1 IKBKAP ING5 KAT5 KAT7 KBTBD7 KRT40 LDOC1 LGALS3 LGALS8 LRIF1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT2A ND1 NFKBIA NPC2 OLA1 PCBP2 PDXK PDZD8 PIAS1 PIAS4 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 XRCC6 ZFP64 ZHX1 ZNF121
Entrez ID		4502	580
HPRD ID		08863	03354
Ensembl ID			ENSG00000138376
Uniprot IDs		P02795	Q99728
PDB IDs		1MHU 2MHU	1JM7 2NTE 2R1Z 3C5R 3FA2
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Argininosuccinate Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Primary Spermatocyte Growth Cellular Response To Stress Positive Regulation Of Histone Modification Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Protein Kinase D Signaling Negative Regulation Of MRNA 3'-end Processing Cellular Response To Amine Stimulus Response To Mycotoxin Positive Regulation Of Histone Deacetylase Activity 'de Novo' UMP Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Modification Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Ionizing Radiation Regulation Of Metabolic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Deacetylase Activity Positive Regulation Of Cell Death 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Response To Purine-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Aspartate Metabolic Process Arginine Biosynthetic Process Protein K6-linked Ubiquitination Cellular Response To Laminar Fluid Shear Stress Cellular Response To Oleic Acid Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Chorion Development Positive Regulation Of Endothelial Cell Chemotaxis Cellular Response To Oxidative Stress Anatomical Structure Development Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Regulation Of Nucleocytoplasmic Transport Diaphragm Development	Cellular Response To DNA Damage Stimulus DNA Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process Double-strand Break Repair DNA Metabolic Process Gene Expression Chromosome Organization Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Protein Modification By Small Protein Conjugation RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Protein Ubiquitination Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Stress Cell Cycle Checkpoint DNA Recombination Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Meiotic Mismatch Repair Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Modification-dependent Protein Catabolic Process Chromatin Organization DNA Damage Checkpoint Cellular Macromolecule Catabolic Process Immune System Process Viral Process Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?