ADAMTS4 and SERPINA3

Number of citations of the paper that reports this interaction (PMID 16099106)
5

Data Source:
HPRD (two hybrid)

		ADAMTS4	SERPINA3
Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 4	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS			Body mass index ( 23669352)
Protein-Protein Interactions		11 interactors: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		9507	12
HPRD ID		04853	00120
Ensembl ID			ENSG00000196136
Uniprot IDs		O75173	G3V5I3 P01011
PDB IDs		2RJP 3B2Z	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Acute-phase Response Acute Inflammatory Response Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Inflammatory Response Pathogenesis Regulation Of Proteolysis Defense Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Platelet Degranulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Methanol Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Nerve Growth Factor Production Response To Triglyceride Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Response To Inorganic Substance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Secretion By Cell Cell Adhesion Negative Regulation Of Cellular Metabolic Process Response To Chromate Cellular Response To Erythropoietin Nerve Growth Factor Processing Calcium-independent Cell-matrix Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Skeletal System Development Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Serine-type Endopeptidase Activity Male Germ-line Stem Cell Asymmetric Division Secretion Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Negative Regulation Of Serine-type Peptidase Activity	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?		affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?		affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Intersection) ?