MT2A and RCHY1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MT2A	RCHY1
Gene Name		metallothionein 2A	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Drug Binding Zinc Ion Binding	P53 Binding Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Homodimerization Activity
	Biological Process	Cellular Copper Ion Homeostasis Cytokine-mediated Signaling Pathway Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Zinc Ion	Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		13 interactors: ADAMTS4 ASS1 BARD1 CXorf40A DHODH ECT2 JMJD1C PAXIP1 PRKD1 RCHY1 SHBG SPINK7 USP25	61 interactors: ADAMTSL4 AIG1 AOX1 AR ARF4 ATN1 BIRC3 C19orf80 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DCUN1D5 F7 FADS6 GFI1B GORAB HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NL PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBE2D2 UBE2D4 WDR74 ZNF160
Entrez ID		4502	25898
HPRD ID		08863	07607
Ensembl ID			ENSG00000163743
Uniprot IDs		P02795	C7E542 E7EMC8 E7ETW5 J3KPI0 Q96PM5
PDB IDs		1MHU 2MHU	2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Argininosuccinate Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Primary Spermatocyte Growth Cellular Response To Stress Positive Regulation Of Histone Modification Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Protein Kinase D Signaling Negative Regulation Of MRNA 3'-end Processing Cellular Response To Amine Stimulus Response To Mycotoxin Positive Regulation Of Histone Deacetylase Activity 'de Novo' UMP Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Modification Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Ionizing Radiation Regulation Of Metabolic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Deacetylase Activity Positive Regulation Of Cell Death 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Response To Purine-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Aspartate Metabolic Process Arginine Biosynthetic Process Protein K6-linked Ubiquitination Cellular Response To Laminar Fluid Shear Stress Cellular Response To Oleic Acid Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Chorion Development Positive Regulation Of Endothelial Cell Chemotaxis Cellular Response To Oxidative Stress Anatomical Structure Development Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Regulation Of Nucleocytoplasmic Transport Diaphragm Development	Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Protein Metabolic Process Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process Cellular Response To DNA Damage Stimulus Cell Cycle Process Positive Regulation Of Metabolic Process Cell Death Death Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process Response To Abiotic Stimulus Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Negative Regulation Of Programmed Cell Death
Tagcloud ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination
Tagcloud (Difference) ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination
Tagcloud (Intersection) ?