MT2A and DHODH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MT2A	DHODH
Gene Name		metallothionein 2A	dihydroorotate dehydrogenase (quinone)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Intrinsic Component Of Mitochondrial Inner Membrane Neuronal Cell Body
	Molecular Function	Protein Binding Drug Binding Zinc Ion Binding	Dihydroorotate Dehydrogenase Activity Drug Binding FMN Binding Ubiquinone Binding
	Biological Process	Cellular Copper Ion Homeostasis Cytokine-mediated Signaling Pathway Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Zinc Ion	Pyrimidine Nucleobase Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Female Pregnancy Lactation Response To Caffeine Response To Drug Response To Starvation Positive Regulation Of Apoptotic Process 'de Novo' UMP Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Fission
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Pyrimidine biosynthesis Pyrimidine metabolism Metabolism of nucleotides
Drugs			Leflunomide Atovaquone Orotic Acid Decylamine-N,N-Dimethyl-N-Oxide Riboflavin Monophosphate Brequinar Analog 6-Fluoro-2-(2\'-Fluoro-1,1\'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid Antiproliferative Agent A771726 Lauryl Dimethylamine-N-Oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-(AMINOCARBONYL)-1,1\':4\',1\'\'-TERPHENYL-3-CARBOXYLICACID (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2\'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3\'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3\'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2\'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		13 interactors: ADAMTS4 ASS1 BARD1 CXorf40A DHODH ECT2 JMJD1C PAXIP1 PRKD1 RCHY1 SHBG SPINK7 USP25	2 interactors: MT2A TMED10
Entrez ID		4502	1723
HPRD ID		08863	00521
Ensembl ID			ENSG00000102967
Uniprot IDs		P02795	Q02127
PDB IDs		1MHU 2MHU	1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3ZWS 3ZWT 4IGH
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Argininosuccinate Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Primary Spermatocyte Growth Cellular Response To Stress Positive Regulation Of Histone Modification Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Protein Kinase D Signaling Negative Regulation Of MRNA 3'-end Processing Cellular Response To Amine Stimulus Response To Mycotoxin Positive Regulation Of Histone Deacetylase Activity 'de Novo' UMP Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Modification Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Ionizing Radiation Regulation Of Metabolic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Deacetylase Activity Positive Regulation Of Cell Death 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Response To Purine-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Aspartate Metabolic Process Arginine Biosynthetic Process Protein K6-linked Ubiquitination Cellular Response To Laminar Fluid Shear Stress Cellular Response To Oleic Acid Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Chorion Development Positive Regulation Of Endothelial Cell Chemotaxis Cellular Response To Oxidative Stress Anatomical Structure Development Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Regulation Of Nucleocytoplasmic Transport Diaphragm Development	Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Cargo Loading Into Vesicle COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Cellular Copper Ion Homeostasis Cellular Response To Zinc Ion COPII Vesicle Coating Regulation Of Beta-amyloid Formation Copper Ion Homeostasis COPII-coated Vesicle Budding Regulation Of Amyloid Precursor Protein Catabolic Process Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Response To Zinc Ion Regulated Secretory Pathway Cellular Response To Drug Golgi Organization Membrane Budding ER To Golgi Vesicle-mediated Transport Interferon-gamma-mediated Signaling Pathway Cellular Response To Metal Ion Response To Organic Substance Cellular Response To Inorganic Substance Response To Alkaloid Cellular Response To Interferon-gamma Transition Metal Ion Homeostasis Response To Interferon-gamma
Tagcloud ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	bc1 biosynthesis catalyzed chain cytochrome de dehydrogenase dihydroorotate downregulation electron experiment iii impairment interference leads mitochondrial novo orotate programmed pyrimidine respiratory showing supplementation supported suppression suppressor transport triggered uridine
Tagcloud (Difference) ?		22rv1 bax beclin cflar cisplatin consequently create hif1alpha ic50 ions kappab1 kras mt1a mtt participate pc pnt1a prostatic regard resistance short summary survivin term tumorous verified zinc zip1 znt	bc1 biosynthesis catalyzed chain cytochrome de dehydrogenase dihydroorotate downregulation electron experiment iii impairment interference leads mitochondrial novo orotate programmed pyrimidine respiratory showing supplementation supported suppression suppressor transport triggered uridine
Tagcloud (Intersection) ?