MCL1 and USP9X

Number of citations of the paper that reports this interaction (PMID 23097624)
5

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		MCL1	USP9X
Gene Name		myeloid cell leukemia 1	ubiquitin specific peptidase 9, X-linked
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex	Cytoplasm Cytosol Membrane Growth Cone Apical Part Of Cell
	Molecular Function	Protein Binding Protein Channel Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding
	Biological Process	Cell Fate Determination Multicellular Organismal Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Cellular Homeostasis Response To Cytokine Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Neuron Migration Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Post-embryonic Development Gene Expression Protein Deubiquitination Cerebellar Cortex Structural Organization Hippocampus Development BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axon Extension Cell Division Regulation Of Proteasomal Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		29 interactors: BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK CASP3 DAD1 FBXW7 GSK3A GSK3B HRK HUWE1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 TNKS TP53 TPT1 TRAF6 UHRF2 USP9X VDAC1	13 interactors: CTNNB1 DCX ERG GPSM1 MAP3K5 MCL1 MLLT4 PEX5 PSD4 SMAD2 SMAD4 SMURF1 UBC
Entrez ID		4170	8239
HPRD ID		08870	02091
Ensembl ID		ENSG00000143384	ENSG00000124486
Uniprot IDs		C8YZ26 Q07820	Q6P468 Q86X58 Q93008
PDB IDs		2KBW 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 4HW2 4HW3 4HW4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Apoptotic Process Release Of Cytochrome C From Mitochondria Programmed Cell Death Cell Death Death Regulation Of Protein Oligomerization Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Organelle Organization Positive Regulation Of Protein Homooligomerization Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Mitochondrial Membrane Organization Positive Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Protein Complex Assembly Cellular Response To DNA Damage Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Peptidase Activity	Regulation Of Cellular Response To Growth Factor Stimulus Cell Differentiation Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Axis Specification Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Stem Cell Differentiation Response To Transforming Growth Factor Beta Regulation Of Epithelial To Mesenchymal Transition Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Endoderm Development Embryonic Pattern Specification Response To Growth Factor Regulation Of BMP Signaling Pathway Endothelium Development Cell Fate Commitment SMAD Protein Complex Assembly Intracellular Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Axis Specification Positive Regulation Of Signal Transduction Mesonephros Development Signal Transduction Embryonic Foregut Morphogenesis Foregut Morphogenesis Protein Localization To Cell Surface Dorsal/ventral Axis Specification Ectoderm Development Kidney Epithelium Development Stem Cell Maintenance Signaling Establishment Of Endothelial Barrier Regulation Of Heart Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Neuron Migration Cell Communication Transcription Initiation From RNA Polymerase II Promoter Gastrulation Regulation Of Cellular Process
Tagcloud ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	address adjuvant attenuation biomarker candidate causing define deubiquitinase differential downregulator driven elusive endocrine eralpha experiencing fulvestrant luminal prevented problem receive responsive rnai screen signature stabilize sufficient tamoxifen widely zr
Tagcloud (Difference) ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	address adjuvant attenuation biomarker candidate causing define deubiquitinase differential downregulator driven elusive endocrine eralpha experiencing fulvestrant luminal prevented problem receive responsive rnai screen signature stabilize sufficient tamoxifen widely zr
Tagcloud (Intersection) ?