MCL1 and TPT1

Number of citations of the paper that reports this interaction (PMID 11598139)
48

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MCL1	TPT1
Gene Name		myeloid cell leukemia 1	tumor protein, translationally-controlled 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex	Extracellular Space Nucleus Cytoplasm Multivesicular Body Tubulin Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Channel Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Calcium Ion Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Cell Fate Determination Multicellular Organismal Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Cellular Homeostasis Response To Cytokine Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Drugs
Diseases
GWAS		Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		29 interactors: BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK CASP3 DAD1 FBXW7 GSK3A GSK3B HRK HUWE1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 TNKS TP53 TPT1 TRAF6 UHRF2 USP9X VDAC1	25 interactors: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1D FANCA IKBKG LIG4 MCL1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A
Entrez ID		4170	7178
HPRD ID		08870	15979
Ensembl ID		ENSG00000143384	ENSG00000133112
Uniprot IDs		C8YZ26 Q07820	P13693 Q8TBK7
PDB IDs		2KBW 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 4HW2 4HW3 4HW4	1YZ1 2HR9 3EBM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Apoptotic Process Release Of Cytochrome C From Mitochondria Programmed Cell Death Cell Death Death Regulation Of Protein Oligomerization Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Organelle Organization Positive Regulation Of Protein Homooligomerization Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Mitochondrial Membrane Organization Positive Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Protein Complex Assembly Cellular Response To DNA Damage Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Peptidase Activity	Regulation Of Response To DNA Damage Stimulus Cell Communication By Electrical Coupling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stimulus Cellular Response To DNA Damage Stimulus Response To Organic Cyclic Compound Response To Glycoside Apoptotic Process Regulation Of The Force Of Heart Contraction Response To Radiation Programmed Cell Death Positive Regulation Of Mitotic Cell Cycle Cell Death Death Response To Steroid Hormone Response To Abiotic Stimulus Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Stress Sodium Ion Export From Cell Response To Lipid Regulation Of Signaling Cardiac Muscle Contraction Response To Stimulus Regulation Of Heart Contraction Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Sodium Ion Export Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Potassium Ion Homeostasis Cellular Response To Steroid Hormone Stimulus Neuron Death Cell Cycle Heart Contraction Cellular Response To Organic Cyclic Compound Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Cellular Localization Cellular Response To Lipid Regulation Of Cardiac Muscle Contraction Regulation Of Neurogenesis Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Apoptotic Process Muscle Contraction Regulation Of Cellular Process Negative Regulation Of Mitotic Cell Cycle Cellular Localization
Tagcloud ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	2o2 activating adds antioxidant avenue challenge chemoresistance complexity contain continuously correlation differentially direct diverse element existed fact lung maintains minimize mutated network open p53 promote responsive reversion stability upregulates
Tagcloud (Difference) ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	2o2 activating adds antioxidant avenue challenge chemoresistance complexity contain continuously correlation differentially direct diverse element existed fact lung maintains minimize mutated network open p53 promote responsive reversion stability upregulates
Tagcloud (Intersection) ?