MCL1 and BIK

Number of citations of the paper that reports this interaction (PMID 16697956)
236

Data Source:
HPRD (in vitro)

		MCL1	BIK
Gene Name		myeloid cell leukemia 1	BCL2-interacting killer (apoptosis-inducing)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Protein Channel Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Protein Binding Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Cell Fate Determination Multicellular Organismal Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Cellular Homeostasis Response To Cytokine Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Spermatogenesis Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein Homooligomerization Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Drugs
Diseases
GWAS		Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)	Prostate cancer ( 21743057)
Protein-Protein Interactions		29 interactors: BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK CASP3 DAD1 FBXW7 GSK3A GSK3B HRK HUWE1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 TNKS TP53 TPT1 TRAF6 UHRF2 USP9X VDAC1	11 interactors: APP BCL2 BCL2A1 BCL2L1 BCL2L2 CRKL FATE1 MCL1 NR2F2 SOCS3 TANK
Entrez ID		4170	638
HPRD ID		08870	04547
Ensembl ID		ENSG00000143384	ENSG00000100290
Uniprot IDs		C8YZ26 Q07820	Q13323
PDB IDs		2KBW 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 4HW2 4HW3 4HW4	2IPE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Apoptotic Process Release Of Cytochrome C From Mitochondria Programmed Cell Death Cell Death Death Regulation Of Protein Oligomerization Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Organelle Organization Positive Regulation Of Protein Homooligomerization Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Mitochondrial Membrane Organization Positive Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Protein Complex Assembly Cellular Response To DNA Damage Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Peptidase Activity	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Anoikis Intracellular Signal Transduction Apoptotic Signaling Pathway Response To Stress Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Signaling Negative Regulation Of Programmed Cell Death Cell Communication Apoptotic Process Reproductive Structure Development Negative Regulation Of Cell Death Reproductive System Development Intracellular Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction Cell Death Regulation Of Signal Transduction Neuron Apoptotic Process Death Negative Regulation Of Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Death Negative Regulation Of Signaling Apoptotic Mitochondrial Changes Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Reproductive Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Sexual Reproduction Innate Immune Response Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Stimulus
Tagcloud ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	abt actinomycin antagonism antagonizing bak bcl bh3 carfilzomib concurrent crc cyclohexamide ectopic ectopically enabled irreversible isogenic kras mimetic noxa overcome potently sensitized sequestered shrna synergistic synergistically synergy ultimately xl
Tagcloud (Difference) ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	abt actinomycin antagonism antagonizing bak bcl bh3 carfilzomib concurrent crc cyclohexamide ectopic ectopically enabled irreversible isogenic kras mimetic noxa overcome potently sensitized sequestered shrna synergistic synergistically synergy ultimately xl
Tagcloud (Intersection) ?