MCL1 and UHRF2

Number of citations of the paper that reports this interaction (PMID 21952639)
4

Data Source:
BioGRID (far western blotting)

		MCL1	UHRF2
Gene Name		myeloid cell leukemia 1	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex	Nucleus Nucleoplasm Nuclear Heterochromatin
	Molecular Function	Protein Binding Protein Channel Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Fate Determination Multicellular Organismal Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Cellular Homeostasis Response To Cytokine Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Cell Proliferation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest
Pathways
Drugs
Diseases
GWAS		Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)	Periodontal microbiota ( 22699663)
Protein-Protein Interactions		29 interactors: BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK CASP3 DAD1 FBXW7 GSK3A GSK3B HRK HUWE1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 TNKS TP53 TPT1 TRAF6 UHRF2 USP9X VDAC1	37 interactors: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 FYN HDAC1 HIST1H3A JAK3 LCK LYN MCL1 PCNA PCNP PTPRC RAD51 RB1 RBCK1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2W USP7 YY1
Entrez ID		4170	115426
HPRD ID		08870	18257
Ensembl ID		ENSG00000143384	ENSG00000147854
Uniprot IDs		C8YZ26 Q07820	Q96PU4
PDB IDs		2KBW 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 4HW2 4HW3 4HW4	1WY8 1Z6U 2E6S 3OLN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Apoptotic Process Release Of Cytochrome C From Mitochondria Programmed Cell Death Cell Death Death Regulation Of Protein Oligomerization Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Organelle Organization Positive Regulation Of Protein Homooligomerization Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Mitochondrial Membrane Organization Positive Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Protein Complex Assembly Cellular Response To DNA Damage Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Peptidase Activity	Response To Stress Cellular Response To Stimulus Response To Stimulus Response To Organic Substance Response To Abiotic Stimulus Regulation Of Immune System Process Signaling Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Signal Transduction Cell Communication Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To DNA Damage Stimulus Regulation Of Cell Proliferation Cellular Response To Stress Regulation Of Cell Death Positive Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle Process Cell Cycle Phase Transition Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Protein Ubiquitination Positive Regulation Of Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death
Tagcloud ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1
Tagcloud (Difference) ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1
Tagcloud (Intersection) ?