MCL1 and BBC3

Number of citations of the paper that reports this interaction (PMID 15721256)
297

Data Source:
BioGRID (unspecified method, affinity chromatography technology)
HPRD (in vitro)

		MCL1	BBC3
Gene Name		myeloid cell leukemia 1	BCL2 binding component 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Protein Binding Protein Channel Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Protein Binding
	Biological Process	Cell Fate Determination Multicellular Organismal Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Cellular Homeostasis Response To Cytokine Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Determination Of Adult Lifespan Positive Regulation Of Protein Homooligomerization Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Activation of PUMA and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		29 interactors: BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK CASP3 DAD1 FBXW7 GSK3A GSK3B HRK HUWE1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 TNKS TP53 TPT1 TRAF6 UHRF2 USP9X VDAC1	6 interactors: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 MCL1
Entrez ID		4170	27113
HPRD ID		08870	16165
Ensembl ID		ENSG00000143384	ENSG00000105327
Uniprot IDs		C8YZ26 Q07820	Q96PG8 Q9BXH1
PDB IDs		2KBW 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 4HW2 4HW3 4HW4	2M04 4HNJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Oligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Apoptotic Process Release Of Cytochrome C From Mitochondria Programmed Cell Death Cell Death Death Regulation Of Protein Oligomerization Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Organelle Organization Positive Regulation Of Protein Homooligomerization Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Mitochondrial Membrane Organization Positive Regulation Of Protein Metabolic Process Zymogen Activation Positive Regulation Of Protein Complex Assembly Cellular Response To DNA Damage Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Peptidase Activity	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Anoikis Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Regulation Of Anoikis Cell Death Death Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Male Gonad Development Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Potential Male Sex Differentiation Regulation Of Mitochondrial Membrane Permeability Regulation Of Apoptotic Process Regulation Of Membrane Permeability Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Regulation Of Cell Death Gonad Development Development Of Primary Sexual Characteristics Regulation Of Nitrogen Utilization Regulation Of Neuron Apoptotic Process Response To Gamma Radiation Regulation Of Intracellular Signal Transduction Neuron Apoptotic Process Intracellular Signal Transduction Sertoli Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sex Differentiation Regulation Of Neuron Death Mitochondrial Membrane Organization Neuron Death Ovarian Follicle Development
Tagcloud ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	abrogated abundance antiapoptotic barely bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Difference) ?		34a bcl6 bim btk buffering dlbcl doi fluctuations follicular foxp1 gab1 immunoglobulins intimately leu lymphocytic mantle marginal mirnas modulators myb niches preview pu put stochastic subtle summarizing tcl1 zap	abrogated abundance antiapoptotic barely bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing
Tagcloud (Intersection) ?