LRPAP1 and LRP8

Number of citations of the paper that reports this interaction (PMID 12899622)
7

Data Source:
HPRD (in vivo)

		LRPAP1	LRP8
Gene Name		low density lipoprotein receptor-related protein associated protein 1	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Plasma Membrane Cell Surface Integral Component Of Membrane Vesicle Rough Endoplasmic Reticulum Lumen	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Heparin Binding Lipase Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Very-low-density Lipoprotein Particle Receptor Binding	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Reelin Receptor Activity
	Biological Process	Protein Folding Receptor-mediated Endocytosis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Vesicle-mediated Transport Negative Regulation Of Protein Binding Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Beta-amyloid Clearance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Signal Transduction Blood Coagulation Phototransduction, Visible Light Cytokine-mediated Signaling Pathway Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways			Visual phototransduction Platelet homeostasis Platelet sensitization by LDL Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Body mass index (interaction) ( 23192594)
Protein-Protein Interactions		18 interactors: ETV7 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALA RALGDS RANBP2 RTN4 SORL1 SORT1 VLDLR	19 interactors: ANAPC10 APBA2 APOE APOH CLU DAB1 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		4043	7804
HPRD ID		00082	04002
Ensembl ID
Uniprot IDs		P30533	Q14114
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03	3A7Q
Enriched GO Terms of Interacting Partners?		Receptor-mediated Endocytosis Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Phototransduction, Visible Light Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Retinoid Metabolic Process Transport Ras Protein Signal Transduction Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Signal Transduction Regulation Of Kinase Activity Steroid Metabolic Process Detection Of Light Stimulus Cholesterol Metabolic Process Signaling Isoprenoid Metabolic Process Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Sterol Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Golgi Inheritance Regulation Of Cellular Component Organization Alcohol Metabolic Process Caveolin-mediated Endocytosis Regulation Of Phosphorus Metabolic Process Detection Of Abiotic Stimulus Response To Abiotic Stimulus Reelin-mediated Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Golgi Organization Cellular Response To Stimulus Activation Of MAPKK Activity Positive Regulation Of Protein Kinase Activity Locomotion Response To External Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Response To Organic Substance Regulation Of Early Endosome To Late Endosome Transport Viral Process	Regulation Of Beta-amyloid Clearance Membrane Depolarization Regulation Of Signaling Receptor Clustering Regulation Of Cellular Protein Metabolic Process Regulation Of Membrane Potential Positive Regulation Of Catalytic Activity Regulation Of Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Ion Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Catalytic Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Cell-cell Signaling Positive Regulation Of Protein Modification Process Social Behavior Learning Dendrite Development Regulation Of Ion Transmembrane Transporter Activity Behavior Positive Regulation Of Membrane Potential Regulation Of Transmembrane Transporter Activity Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Synaptic Plasticity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering
Tagcloud ?			aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Difference) ?			aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Intersection) ?