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LRPAP1 and SORL1
Number of citations of the paper that reports this interaction (PMID
8940146
)
40
Data Source:
HPRD
(in vitro, in vivo)
LRPAP1
SORL1
Gene Name
low density lipoprotein receptor-related protein associated protein 1
sortilin-related receptor, L(DLR class) A repeats containing
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Endoplasmic Reticulum
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Vesicle
Rough Endoplasmic Reticulum Lumen
Extracellular Space
Nuclear Envelope Lumen
Endosome
Early Endosome
Multivesicular Body
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Integral Component Of Plasma Membrane
Membrane
Golgi Cisterna
Low-density Lipoprotein Particle
Neuronal Cell Body
Recycling Endosome
Extracellular Vesicular Exosome
Molecular Function
Asialoglycoprotein Receptor Activity
Protein Binding
Heparin Binding
Lipase Binding
Receptor Antagonist Activity
Low-density Lipoprotein Particle Receptor Binding
Unfolded Protein Binding
Very-low-density Lipoprotein Particle Receptor Binding
Beta-amyloid Binding
Transmembrane Signaling Receptor Activity
Protein Binding
Low-density Lipoprotein Particle Binding
ADP-ribosylation Factor Binding
Biological Process
Protein Folding
Receptor-mediated Endocytosis
Negative Regulation Of Very-low-density Lipoprotein Particle Clearance
Vesicle-mediated Transport
Negative Regulation Of Protein Binding
Extracellular Negative Regulation Of Signal Transduction
Negative Regulation Of Beta-amyloid Clearance
Protein Targeting To Golgi
Protein Targeting
Protein Targeting To Lysosome
Lipid Transport
Post-Golgi Vesicle-mediated Transport
Receptor-mediated Endocytosis
Signal Transduction
Cholesterol Metabolic Process
Cell Proliferation
Regulation Of Smooth Muscle Cell Migration
Cell Migration
Negative Regulation Of Protein Binding
Negative Regulation Of Protein Oligomerization
Negative Regulation Of MAP Kinase Activity
Protein Retention In Golgi Apparatus
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Neurogenesis
Protein Maturation
Positive Regulation Of Protein Exit From Endoplasmic Reticulum
Negative Regulation Of Neuron Death
Negative Regulation Of Beta-amyloid Formation
Positive Regulation Of Choline O-acetyltransferase Activity
Negative Regulation Of Tau-protein Kinase Activity
Positive Regulation Of ER To Golgi Vesicle-mediated Transport
Positive Regulation Of Early Endosome To Recycling Endosome Transport
Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Localization To Early Endosome
Negative Regulation Of Neurofibrillary Tangle Assembly
Positive Regulation Of Endocytic Recycling
Pathways
Drugs
Diseases
GWAS
Alzheimer's disease (late onset) (
23565137
)
Cardiovascular disease risk factors (
20838585
)
Protein-Protein Interactions
18 interactors:
ETV7
LDLR
LRP1
LRP1B
LRP2
LRP8
MAPK1
MAPK3
POLA2
PPM1G
RAF1
RALA
RALGDS
RANBP2
RTN4
SORL1
SORT1
VLDLR
5 interactors:
FURIN
GGA1
GGA2
LRPAP1
PPP1CA
Entrez ID
4043
6653
HPRD ID
00082
03595
Ensembl ID
ENSG00000137642
Uniprot IDs
P30533
E9PP43
Q92673
PDB IDs
1LRE
1NRE
1OP1
1OV2
2FCW
2FTU
2FYL
2P01
2P03
2DM4
3G2S
3G2T
Enriched GO Terms of Interacting Partners
?
Receptor-mediated Endocytosis
Endocytosis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Vesicle-mediated Transport
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Phototransduction, Visible Light
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Retinoid Metabolic Process
Transport
Ras Protein Signal Transduction
Diterpenoid Metabolic Process
Detection Of Visible Light
Phototransduction
Signal Transduction
Regulation Of Kinase Activity
Steroid Metabolic Process
Detection Of Light Stimulus
Cholesterol Metabolic Process
Signaling
Isoprenoid Metabolic Process
Regulation Of Catalytic Activity
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Transferase Activity
Sterol Metabolic Process
Cell Communication
Cell Surface Receptor Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Golgi Inheritance
Regulation Of Cellular Component Organization
Alcohol Metabolic Process
Caveolin-mediated Endocytosis
Regulation Of Phosphorus Metabolic Process
Detection Of Abiotic Stimulus
Response To Abiotic Stimulus
Reelin-mediated Signaling Pathway
Regulation Of Protein Kinase Activity
Regulation Of Golgi Organization
Cellular Response To Stimulus
Activation Of MAPKK Activity
Positive Regulation Of Protein Kinase Activity
Locomotion
Response To External Stimulus
Positive Regulation Of Kinase Activity
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Phosphorylation
Response To Organic Substance
Regulation Of Early Endosome To Late Endosome Transport
Viral Process
Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Nerve Growth Factor Production
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Beta-amyloid Clearance
Negative Regulation Of Transforming Growth Factor Beta1 Production
Negative Regulation Of Receptor Catabolic Process
Response To Transforming Growth Factor Beta
Negative Regulation Of Very-low-density Lipoprotein Particle Clearance
Nerve Growth Factor Processing
Positive Regulation Of Protein Catabolic Process
Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Production
Regulation Of Beta-amyloid Clearance
Regulation Of Glycogen Catabolic Process
Vesicle-mediated Transport
Viral Protein Processing
Regulation Of Protein Catabolic Process
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Peptidyl-glutamic Acid Carboxylation
Extracellular Negative Regulation Of Signal Transduction
Signal Peptide Processing
Triglyceride Catabolic Process
Entrainment Of Circadian Clock By Photoperiod
Virion Assembly
Establishment Of Localization In Cell
Negative Regulation Of Receptor Activity
Photoperiodism
Entrainment Of Circadian Clock
Acylglycerol Catabolic Process
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Peptide Biosynthetic Process
Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Peptide Hormone Processing
Transport
Regulation Of Glycogen Metabolic Process
Cellular Localization
Negative Regulation Of Protein Binding
Glycogen Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signal Transduction
Intracellular Protein Transport
Collagen Catabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Generation Of Precursor Metabolites And Energy
Negative Regulation Of Cellular Protein Catabolic Process
Circadian Regulation Of Gene Expression
Tagcloud
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
casp3
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
psen2
snps
sporadic
triggers
turn
unlikely
Tagcloud (Difference)
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
casp3
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
psen2
snps
sporadic
triggers
turn
unlikely
Tagcloud (Intersection)
?