SORL1 and FURIN

Number of citations of the paper that reports this interaction (PMID 11294867)
26

Data Source:
HPRD (in vitro)

		SORL1	FURIN
Gene Name		sortilin-related receptor, L(DLR class) A repeats containing	furin (paired basic amino acid cleaving enzyme)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Golgi Cisterna Low-density Lipoprotein Particle Neuronal Cell Body Recycling Endosome Extracellular Vesicular Exosome	Golgi Membrane Extracellular Space Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Trans-Golgi Network Transport Vesicle Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Beta-amyloid Binding Transmembrane Signaling Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding ADP-ribosylation Factor Binding	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding
	Biological Process	Protein Targeting To Golgi Protein Targeting Protein Targeting To Lysosome Lipid Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Signal Transduction Cholesterol Metabolic Process Cell Proliferation Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Protein Binding Negative Regulation Of Protein Oligomerization Negative Regulation Of MAP Kinase Activity Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Negative Regulation Of Neurogenesis Protein Maturation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Neuron Death Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Choline O-acetyltransferase Activity Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Endocytic Recycling	Signal Peptide Processing Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Pathogenesis Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Viral Process Protein Processing Peptide Hormone Processing Peptidyl-glutamic Acid Carboxylation Viral Life Cycle Virion Assembly Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Nerve Growth Factor Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity
Pathways			Loss of Function of TGFBR2 in Cancer Elastic fibre formation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Degradation of the extracellular matrix Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Assembly Of The HIV Virion HIV Life Cycle Uptake and actions of bacterial toxins NGF processing Removal of aminoterminal propeptides from gamma-carboxylated proteins Pre-NOTCH Expression and Processing Uptake and function of anthrax toxins Signaling by NODAL Signaling by PDGF Signalling by NGF TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Pre-NOTCH Processing in Golgi Loss of Function of SMAD2/3 in Cancer Post-translational protein modification Collagen degradation Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Activation of Matrix Metalloproteinases Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Synthesis and processing of ENV and VPU Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Gamma carboxylation, hypusine formation and arylsulfatase activation SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 23565137) Cardiovascular disease risk factors ( 20838585)	Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		5 interactors: FURIN GGA1 GGA2 LRPAP1 PPP1CA	27 interactors: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 COL23A1 DSG3 EDA FLNA FLNC ITM2C LECT1 LRP1 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4
Entrez ID		6653	5045
HPRD ID		03595	00653
Ensembl ID		ENSG00000137642	ENSG00000140564
Uniprot IDs		E9PP43 Q92673	P09958
PDB IDs		2DM4 3G2S 3G2T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Nerve Growth Factor Production Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Nerve Growth Factor Processing Positive Regulation Of Protein Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Beta-amyloid Clearance Regulation Of Glycogen Catabolic Process Vesicle-mediated Transport Viral Protein Processing Regulation Of Protein Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Extracellular Negative Regulation Of Signal Transduction Signal Peptide Processing Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Virion Assembly Establishment Of Localization In Cell Negative Regulation Of Receptor Activity Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptide Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peptide Hormone Processing Transport Regulation Of Glycogen Metabolic Process Cellular Localization Negative Regulation Of Protein Binding Glycogen Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Intracellular Protein Transport Collagen Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Cellular Protein Catabolic Process Circadian Regulation Of Gene Expression	Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Acrosome Reaction Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Multicellular Organismal Development Developmental Process Anatomical Structure Development Regulation Of Acrosome Reaction Platelet Degranulation Protein Targeting To Lysosome Regulation Of Cellular Localization Protein Localization To Lysosome Vesicle-mediated Transport Positive Regulation Of Transport Establishment Of Protein Localization Cellular Localization Hair Follicle Development Positive Regulation Of Humoral Immune Response Hair Cycle Process Positive Regulation Of Calcium Ion-dependent Exocytosis System Development Membrane Protein Ectodomain Proteolysis Secretion By Cell Protein Targeting To Golgi Hair Cycle Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Protein Targeting To Vacuole Regulation Of Defense Response To Virus By Virus Establishment Of Protein Localization To Vacuole Regulation Of Immune System Process Regulation Of Cell Migration Heart Trabecula Morphogenesis Protein Kinase C Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Exocytosis Regulation Of Cell Motility Secretion Protein Transport Regulation Of Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Membrane Protein Proteolysis Regulation Of Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport Protein Localization To Golgi Apparatus Protein Localization Regulation Of Locomotion
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely	autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely	autophosphorylation c5 cleavage cleave cleaved convertases d4 endoproteolytic exclude greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Intersection) ?