LMX1B and LDB1

Number of citations of the paper that reports this interaction (PMID 12792813)
4

Data Source:
HPRD (two hybrid)

		LMX1B	LDB1
Gene Name		LIM homeobox transcription factor 1, beta	LIM domain binding 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleus Transcription Factor Complex Protein Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association
	Biological Process	In Utero Embryonic Development Neuron Migration Trabecular Meshwork Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cell Proliferation Dorsal/ventral Pattern Formation Cerebellum Morphogenesis Central Nervous System Neuron Development Neuron Differentiation Collagen Fibril Organization Midbrain Development Limb Morphogenesis Organ Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Dopaminergic Neuron Differentiation	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Body mass index ( 20935630)
Protein-Protein Interactions		4 interactors: APP LDB1 SSBP3 TCF3	26 interactors: ATXN1 CTDSP1 ESR1 IRAK3 ISL1 LHX2 LHX3 LHX6 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP
Entrez ID		4010	8861
HPRD ID		03986	09144
Ensembl ID		ENSG00000136944	ENSG00000198728
Uniprot IDs		B7ZLH2 O60663 Q6ISE0	Q86U70
PDB IDs			2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?		Brain Development Head Development Central Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Pattern Specification Process Regulation Of Transcription From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Anterior/posterior Axis Specification Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Histone Acetylation Axis Specification Internal Peptidyl-lysine Acetylation Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Histone H3-K4 Acetylation Midbrain-hindbrain Boundary Initiation Prechordal Plate Formation Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protein Acetylation Stem Cell Maintenance Organ Development Positive Regulation Of Hemoglobin Biosynthetic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Anterior Head Development RNA Metabolic Process Embryo Development Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Collateral Sprouting In Absence Of Injury Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Regulation Of Mitotic Cell Cycle Phase Transition Skin Development Regulation Of Cell Cycle Phase Transition Neural Plate Anterior/posterior Regionalization Stem Cell Development Peptidyl-lysine Modification Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Hemoglobin Biosynthetic Process Wnt Signaling Pathway	Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Central Nervous System Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Central Nervous System Development Cellular Metabolic Process Brain Development Head Development Developmental Process Organ Development Anatomical Structure Development Forebrain Development Tube Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Specification Process Cell Differentiation Negative Regulation Of Signal Transduction Multicellular Organismal Development Neuron Differentiation Anatomical Structure Morphogenesis System Development Spinal Cord Motor Neuron Differentiation Generation Of Neurons Negative Regulation Of Signaling Transcription From RNA Polymerase II Promoter Neurogenesis
Tagcloud ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm en1 eventually fgfs limb limbs malformation manners modules organized p63 quantity shh sterile wnt7a zpa	assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose
Tagcloud (Difference) ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm en1 eventually fgfs limb limbs malformation manners modules organized p63 quantity shh sterile wnt7a zpa	assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose
Tagcloud (Intersection) ?