LDB1 and RLIM

Number of citations of the paper that reports this interaction (PMID 11882901)
41

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		LDB1	RLIM
Gene Name		LIM domain binding 1	ring finger protein, LIM domain interacting
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein Complex	Nucleus Nucleoplasm Cytoplasm Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ATXN1 CTDSP1 ESR1 IRAK3 ISL1 LHX2 LHX3 LHX6 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	27 interactors: ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 PDLIM1 REXO1 RPS14 SIN3A SMURF2 SNX17 SS18L1 STAT6 STMN1 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2
Entrez ID		8861	51132
HPRD ID		09144	02304
Ensembl ID		ENSG00000198728	ENSG00000131263
Uniprot IDs		Q86U70	Q9NVW2
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Central Nervous System Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Central Nervous System Development Cellular Metabolic Process Brain Development Head Development Developmental Process Organ Development Anatomical Structure Development Forebrain Development Tube Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Specification Process Cell Differentiation Negative Regulation Of Signal Transduction Multicellular Organismal Development Neuron Differentiation Anatomical Structure Morphogenesis System Development Spinal Cord Motor Neuron Differentiation Generation Of Neurons Negative Regulation Of Signaling Transcription From RNA Polymerase II Promoter Neurogenesis	Protein K48-linked Ubiquitination Protein Polyubiquitination Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Activation Of Innate Immune Response Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Innate Immune Response RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Protein K11-linked Ubiquitination Negative Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stimulus Positive Regulation Of Immune Response Gene Expression Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Immune System Process Regulation Of Innate Immune Response System Development Mitotic Spindle Assembly Checkpoint
Tagcloud ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Difference) ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Intersection) ?		lim