LDB1 and TOLLIP

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		LDB1	TOLLIP
Gene Name		LIM domain binding 1	toll interacting protein
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein Complex	Cytoplasm Cytosol Nuclear Body Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association	Signal Transducer Activity Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process	Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Innate Immune Response Leukocyte Activation
Pathways			Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ATXN1 CTDSP1 ESR1 IRAK3 ISL1 LHX2 LHX3 LHX6 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	38 interactors: ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPT1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WDYHV1 WRNIP1 XRN2 ZBTB16 ZHX1
Entrez ID		8861	54472
HPRD ID		09144	05887
Ensembl ID		ENSG00000198728	ENSG00000078902
Uniprot IDs		Q86U70	B3KR28 B3KXC6 F2Z2Y8 Q6FIE9 Q9H0E2
PDB IDs		2XJY 2XJZ 2YPA	1WGL
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Central Nervous System Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Central Nervous System Development Cellular Metabolic Process Brain Development Head Development Developmental Process Organ Development Anatomical Structure Development Forebrain Development Tube Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Specification Process Cell Differentiation Negative Regulation Of Signal Transduction Multicellular Organismal Development Neuron Differentiation Anatomical Structure Morphogenesis System Development Spinal Cord Motor Neuron Differentiation Generation Of Neurons Negative Regulation Of Signaling Transcription From RNA Polymerase II Promoter Neurogenesis	Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Transcription, DNA-templated Negative Regulation Of Biosynthetic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Activation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Phosphorylation Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Metabolic Process Gene Expression Regulation Of Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda
Tagcloud (Difference) ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda
Tagcloud (Intersection) ?