IL6 and SH3GL2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IL6	SH3GL2
Gene Name		interleukin 6	SH3-domain GRB2-like 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Interleukin-6 Receptor Complex External Side Of Plasma Membrane	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Protein Kinase Activity Acute-phase Response Inflammatory Response Humoral Immune Response Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Heat Response To Cold Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Lipid Storage Response To Auditory Stimulus Cell Growth Cytokine-mediated Signaling Pathway Platelet Activation Response To Caffeine Endocrine Pancreas Development Neuron Projection Development Response To Nutrient Levels Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Insulin Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Defense Response To Protozoan Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Amino Acid Positive Regulation Of MAPK Cascade Negative Regulation Of Chemokine Biosynthetic Process Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Translation Positive Regulation Of DNA Replication Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JAK-STAT Cascade Response To Antibiotic Muscle Cell Cellular Homeostasis Bone Remodeling Negative Regulation Of Hormone Secretion Negative Regulation Of Muscle Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Response To Calcium Ion Response To Electrical Stimulus Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Transmission Of Nerve Impulse Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus T-helper 17 Cell Lineage Commitment Negative Regulation Of Neuron Death Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization
Pathways		Signaling by GPCR Signaling by FGFR in disease Cellular Senescence FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Senescence-Associated Secretory Phenotype (SASP) Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation	Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs		Ginseng
Diseases
GWAS		C-reactive protein ( 21196492) Dialysis-related mortality ( 21546767)	Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		5 interactors: IL6R IL6ST PTHLH SH3GL2 ZBTB16	53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		3569	6456
HPRD ID		00970	05125
Ensembl ID		ENSG00000136244	ENSG00000107295
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2	B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962
PDB IDs		1ALU 1IL6 1N2Q 1P9M 2IL6	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Ossification Interleukin-6-mediated Signaling Pathway Regulation Of Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of JAK-STAT Cascade System Development Interleukin-11-mediated Signaling Pathway Nipple Sheath Formation Mammary Gland Bud Elongation Regulation Of Osteoblast Differentiation Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Cell Proliferation Hepatic Immune Response Interleukin-27-mediated Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of NK T Cell Differentiation Mammary Gland Bud Morphogenesis Positive Regulation Of Cell-cell Adhesion Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Activation Of Janus Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Cell Activation Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Multicellular Organismal Metabolic Process Cell Differentiation	Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process
Tagcloud ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Difference) ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Intersection) ?