IL6 and ZBTB16

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		IL6	ZBTB16
Gene Name		interleukin 6	zinc finger and BTB domain containing 16
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Interleukin-6 Receptor Complex External Side Of Plasma Membrane	Nucleus Nucleolus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcriptional Repressor Complex
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Double-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Protein Kinase Activity Acute-phase Response Inflammatory Response Humoral Immune Response Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Heat Response To Cold Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Lipid Storage Response To Auditory Stimulus Cell Growth Cytokine-mediated Signaling Pathway Platelet Activation Response To Caffeine Endocrine Pancreas Development Neuron Projection Development Response To Nutrient Levels Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Insulin Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Defense Response To Protozoan Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Amino Acid Positive Regulation Of MAPK Cascade Negative Regulation Of Chemokine Biosynthetic Process Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Translation Positive Regulation Of DNA Replication Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JAK-STAT Cascade Response To Antibiotic Muscle Cell Cellular Homeostasis Bone Remodeling Negative Regulation Of Hormone Secretion Negative Regulation Of Muscle Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Response To Calcium Ion Response To Electrical Stimulus Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Transmission Of Nerve Impulse Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus T-helper 17 Cell Lineage Commitment Negative Regulation Of Neuron Death Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesonephros Development Transcription, DNA-templated Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Signaling by GPCR Signaling by FGFR in disease Cellular Senescence FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Senescence-Associated Secretory Phenotype (SASP) Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		Ginseng
Diseases
GWAS		C-reactive protein ( 21196492) Dialysis-related mortality ( 21546767)	Conduct disorder (interaction) ( 18846501)
Protein-Protein Interactions		5 interactors: IL6R IL6ST PTHLH SH3GL2 ZBTB16	111 interactors: ACP5 ADAMTS4 AGTR1 AGTR2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BMI1 CASP3 CCDC109B CCDC130 CCDC85B CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COQ6 DLST DNAAF5 DNM2 DPM1 EEF1A1 EIF2S2 ENOX1 EP300 EPN1 ESR1 FAM101B FCHO1 FHL2 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX ICAM3 IL6 KIAA1549 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LSM2 LYAR MAGEA11 MAP3K3 NCOR1 NCOR2 NR3C1 PAFAH1B3 PARP1 PGAM5 PLSCR1 PMAIP1 PML PNRC2 PSMD11 PSMD2 QTRT1 RAB27A RARA RB1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TOLLIP TRAF2 TRIM27 TRIM54 TXNIP UBE2I VDR VTA1 WDR33 ZBTB32 ZNF24 ZNF281
Entrez ID		3569	7704
HPRD ID		00970	11762
Ensembl ID		ENSG00000136244	ENSG00000109906
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2	Q05516
PDB IDs		1ALU 1IL6 1N2Q 1P9M 2IL6	1BUO 1CS3
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Ossification Interleukin-6-mediated Signaling Pathway Regulation Of Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of JAK-STAT Cascade System Development Interleukin-11-mediated Signaling Pathway Nipple Sheath Formation Mammary Gland Bud Elongation Regulation Of Osteoblast Differentiation Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Cell Proliferation Hepatic Immune Response Interleukin-27-mediated Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of NK T Cell Differentiation Mammary Gland Bud Morphogenesis Positive Regulation Of Cell-cell Adhesion Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Activation Of Janus Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Cell Activation Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Multicellular Organismal Metabolic Process Cell Differentiation	Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Metabolic Process Response To Organic Substance Developmental Process Transcription, DNA-templated Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Metabolic Process System Development Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Histone H4 Deacetylation Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Protein Deacetylation Gene Expression RNA Metabolic Process Immune System Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Histone H3 Deacetylation Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Chromatin Organization Biosynthetic Process Histone H3-K9 Modification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process
Tagcloud ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Difference) ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Intersection) ?