SH3GL2 and SYNJ2

Number of citations of the paper that reports this interaction (PMID 12456676)
9

Data Source:
BioGRID (pull down)

		SH3GL2	SYNJ2
Gene Name		SH3-domain GRB2-like 2	synaptojanin 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Cytosol Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Nucleotide Binding RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding
	Biological Process	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation
Pathways		Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System	Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)	Cannabis use (initiation) ( 22823124)
Protein-Protein Interactions		53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	7 interactors: GRB2 ITSN1 ITSN2 NCK1 RAC1 SH3GL2 SYNJ2BP
Entrez ID		6456	8871
HPRD ID		05125	10259
Ensembl ID		ENSG00000107295	ENSG00000078269
Uniprot IDs		B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962	B4DG94 O15056
PDB IDs		1X03 1X04 2D4C 2DBM	1UFW
Enriched GO Terms of Interacting Partners?		Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process	Endocytosis Axon Guidance Axonogenesis Positive Regulation Of Signal Transduction Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Regulation Of Signal Transduction Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Signaling Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of Actin Filament Polymerization Cell Morphogenesis Positive Regulation Of Protein Polymerization Neuron Differentiation Cell Projection Organization Locomotion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Complex Assembly Response To Growth Factor Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Movement Of Cell Or Subcellular Component Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Generation Of Neurons Positive Regulation Of Homotypic Cell-cell Adhesion Neurogenesis Regulation Of Receptor Internalization Positive Regulation Of Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Phagocytosis Synaptic Vesicle Endocytosis Cell Development Fc Receptor Signaling Pathway Response To External Stimulus
Tagcloud ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj1 targetable xenografts
Tagcloud (Difference) ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj1 targetable xenografts
Tagcloud (Intersection) ?