SH3GL2 and DACT1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SH3GL2	DACT1
Gene Name		SH3-domain GRB2-like 2	dishevelled-binding antagonist of beta-catenin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Cell Junction Beta-catenin Destruction Complex Synapse
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Protein Kinase C Binding Protein Binding Beta-catenin Binding Protein Kinase A Binding Delta-catenin Binding
	Biological Process	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Stability Regulation Of Catenin Import Into Nucleus Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Embryonic Hindgut Morphogenesis Dendrite Morphogenesis Synapse Organization Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nodal Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	5 interactors: C7orf25 CSNK2B PPP1CC SH3GL2 TK1
Entrez ID		6456	51339
HPRD ID		05125	09709
Ensembl ID		ENSG00000107295	ENSG00000165617
Uniprot IDs		B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962	Q9NYF0
PDB IDs		1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process	Response To External Stimulus Response To Organic Substance Fetal Process Involved In Parturition Skeletal Muscle Cell Proliferation Thymidine Metabolic Process Response To Cortisol Positive Regulation Of Activin Receptor Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process Adiponectin-activated Signaling Pathway Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Axon Guidance Endothelial Tube Morphogenesis Cellular Response To Organic Substance Axonogenesis Parturition Negative Regulation Of Blood Vessel Endothelial Cell Migration Axon Development Cellular Response To Growth Factor Stimulus Triglyceride Catabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Entrainment Of Circadian Clock By Photoperiod Regulation Of Activin Receptor Signaling Pathway Response To Copper Ion Neuron Projection Morphogenesis Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Tube Development Regulation Of Receptor Internalization Cell Morphogenesis Involved In Differentiation Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Pyrimidine Nucleobase Metabolic Process Phosphate-containing Compound Metabolic Process Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Part Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Signaling Negative Regulation Of Epithelial Cell Migration Negative Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	associations blotting ccnd1 ccnd2 dab2 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	associations blotting ccnd1 ccnd2 dab2 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?