SH3GL2 and BIN1

Number of citations of the paper that reports this interaction (PMID 9315708)
11

Data Source:
HPRD (in vitro)

		SH3GL2	BIN1
Gene Name		SH3-domain GRB2-like 2	bridging integrator 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon I Band Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Protein Binding Protein Complex Binding Identical Protein Binding Protein Heterodimerization Activity Tau Protein Binding GTPase Binding RNA Polymerase Binding
	Biological Process	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization	Endocytosis Cell Proliferation Viral Process Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Astrocyte Differentiation Lipid Tube Assembly Regulation Of Cell Cycle Arrest
Pathways		Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)	Alzheimer's disease ( 22832961 21460840 21627779 22005930) Alzheimer's disease (late onset) ( 21460841 21390209)
Protein-Protein Interactions		53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	36 interactors: ABL1 AMPH AP2A1 AP2A2 APP ASAP2 ATXN2 CUX1 DLGAP4 DNM1 DNM2 FBP1 ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC XRCC4 ZBTB3
Entrez ID		6456	274
HPRD ID		05125	03150
Ensembl ID		ENSG00000107295	ENSG00000136717
Uniprot IDs		B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962	B7Z6Y2 O00499 Q9BTH3
PDB IDs		1X03 1X04 2D4C 2DBM	1MUZ 1MV0 1MV3 2FIC 2RMY 2RND
Enriched GO Terms of Interacting Partners?		Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process	Regulation Of Signaling Endocytosis Generation Of Neurons Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Regulation Of ERBB Signaling Pathway Neurogenesis Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Signal Transduction Axon Guidance Neuron Differentiation Neuron Development Nervous System Development Vesicle-mediated Transport Chemotaxis Signaling Neuron Projection Development Locomotion Cell Communication Anatomical Structure Morphogenesis Cell Morphogenesis Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Negative Regulation Of Signaling Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Cell Development Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Blood Coagulation
Tagcloud ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Difference) ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Intersection) ?