IL1B and IL1R2

Number of citations of the paper that reports this interaction (PMID 7878046)
24

Data Source:
HPRD (in vitro)

		IL1B	IL1R2
Gene Name		interleukin 1, beta	interleukin 1 receptor, type II
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Domain Specific Binding	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Fever Generation Positive Regulation Of Protein Phosphorylation Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Embryo Implantation Negative Regulation Of Cell Proliferation Response To Carbohydrate Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Glucose Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Neutrophil Chemotaxis Sequestering Of Triglyceride Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Secretion Interleukin-1 Beta Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Histone Phosphorylation Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Histone Acetylation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Myosin Light Chain Kinase Activity Cellular Response To Drug Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Adiponectin Secretion Monocyte Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Immune Response Cytokine-mediated Signaling Pathway
Pathways		Signaling by Interleukins Interleukin-1 processing Interleukin-1 signaling Cytokine Signaling in Immune system	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs		Minocycline Gallium nitrate Canakinumab Rilonacept
Diseases
GWAS			Ankylosing spondylitis ( 20062062) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		15 interactors: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 PRTN3 SP1	4 interactors: IL1A IL1B IL1RAP IL1RN
Entrez ID		3553	7850
HPRD ID		00985	00995
Ensembl ID		ENSG00000125538	ENSG00000115590
Uniprot IDs		P01584	P27930
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5I1B 6I1B 7I1B 9ILB	3O4O
Enriched GO Terms of Interacting Partners?		Regulation Of Inflammatory Response Cellular Response To Organic Substance Immune System Process Response To Organic Substance Immune Response Cytokine Production Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Stimulus Response To Stimulus Blood Coagulation Hemostasis Platelet Activation Innate Immune Response Response To Stress Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Platelet Degranulation Regulation Of Protein Metabolic Process Interleukin-1-mediated Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Interleukin-1 Beta Production Cell Activation Response To Wounding Cell Differentiation Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Cytokine Biosynthetic Process Regulation Of Signal Transduction Defense Response Response To Organonitrogen Compound Cytokine-mediated Signaling Pathway Cytokine Metabolic Process Cellular Response To Organonitrogen Compound Cellular Response To Acid Chemical Organ Development Response To Carbohydrate Regulation Of Signaling Central Nervous System Development Axonogenesis Peptidyl-tyrosine Autophosphorylation Response To Mechanical Stimulus Dendritic Cell Differentiation	Fever Generation Heat Generation Temperature Homeostasis Acute-phase Response Inflammatory Response Acute Inflammatory Response Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Cytokine Ectopic Germ Cell Programmed Cell Death Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Interleukin-2 Biosynthetic Process Multicellular Organismal Homeostasis Regulation Of Interleukin-2 Biosynthetic Process Immune Response Positive Regulation Vascular Endothelial Growth Factor Production Defense Response Positive Regulation Of Interleukin-2 Production Developmental Programmed Cell Death Positive Regulation Of Mitotic Nuclear Division Regulation Of Vascular Endothelial Growth Factor Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Organic Substance Positive Regulation Of Cytokine Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of MAPK Cascade Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Secretion Extrinsic Apoptotic Signaling Pathway Regulation Of Cytokine Biosynthetic Process Response To Organic Substance Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Nuclear Division Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Positive Regulation Of Myosin Light Chain Kinase Activity Positive Regulation Of Cell Division Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Phosphorylation Cytokine Production Regulation Of Anion Transport Negative Regulation Of Apoptotic Process
Tagcloud ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Difference) ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Intersection) ?		il1b