IL1B and ADRB2

Number of citations of the paper that reports this interaction (PMID 11238007)
4

Data Source:
HPRD (in vitro)

		IL1B	ADRB2
Gene Name		interleukin 1, beta	adrenoceptor beta 2, surface
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule	Nucleus Lysosome Endosome Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Domain Specific Binding	Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Protein Homodimerization Activity Norepinephrine Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Fever Generation Positive Regulation Of Protein Phosphorylation Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Embryo Implantation Negative Regulation Of Cell Proliferation Response To Carbohydrate Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Glucose Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Neutrophil Chemotaxis Sequestering Of Triglyceride Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Secretion Interleukin-1 Beta Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Histone Phosphorylation Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Histone Acetylation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Myosin Light Chain Kinase Activity Cellular Response To Drug Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Adiponectin Secretion Monocyte Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Regulation Of Vasodilation Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway
Pathways		Signaling by Interleukins Interleukin-1 processing Interleukin-1 signaling Cytokine Signaling in Immune system	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Minocycline Gallium nitrate Canakinumab Rilonacept	Betaxolol Metoprolol Norepinephrine Timolol Dipivefrin Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoproterenol Arbutamine Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Procaterol Clenbuterol Bambuterol Oxprenolol Nebivolol Indacaterol Asenapine Droxidopa (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol
Diseases
GWAS
Protein-Protein Interactions		15 interactors: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 PRTN3 SP1	88 interactors: ADRB3 ADRBK1 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNB2L1 GNG2 GNL3L GPR37 GPR56 GPRASP1 GPRC5B GRB2 GRIA3 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1
Entrez ID		3553	154
HPRD ID		00985	00187
Ensembl ID		ENSG00000125538	ENSG00000169252
Uniprot IDs		P01584	P07550
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5I1B 6I1B 7I1B 9ILB	1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO
Enriched GO Terms of Interacting Partners?		Regulation Of Inflammatory Response Cellular Response To Organic Substance Immune System Process Response To Organic Substance Immune Response Cytokine Production Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Stimulus Response To Stimulus Blood Coagulation Hemostasis Platelet Activation Innate Immune Response Response To Stress Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Platelet Degranulation Regulation Of Protein Metabolic Process Interleukin-1-mediated Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Interleukin-1 Beta Production Cell Activation Response To Wounding Cell Differentiation Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Cytokine Biosynthetic Process Regulation Of Signal Transduction Defense Response Response To Organonitrogen Compound Cytokine-mediated Signaling Pathway Cytokine Metabolic Process Cellular Response To Organonitrogen Compound Cellular Response To Acid Chemical Organ Development Response To Carbohydrate Regulation Of Signaling Central Nervous System Development Axonogenesis Peptidyl-tyrosine Autophosphorylation Response To Mechanical Stimulus Dendritic Cell Differentiation	Regulation Of Signal Transduction Regulation Of Signaling Cell Communication Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Process Termination Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Positive Regulation Of Catalytic Activity Hemostasis Wound Healing Response To Wounding Regulation Of Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Cell Activation Dopamine Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell-cell Signaling Regulation Of Cell Motility Positive Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Difference) ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Intersection) ?