IL1R2 and IL1RN

Number of citations of the paper that reports this interaction (PMID 1834644)
9

Data Source:
HPRD (in vivo)

		IL1R2	IL1RN
Gene Name		interleukin 1 receptor, type II	interleukin 1 receptor antagonist
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Extracellular Space Intracellular Cytoplasm Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Immune Response Cytokine-mediated Signaling Pathway	Fever Generation Negative Regulation Of Cytokine-mediated Signaling Pathway Chronic Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Acute-phase Response Immune Response Female Pregnancy Memory Negative Regulation Of Glutamate Secretion Response To Activity Sensory Perception Of Pain Carboxylic Acid Metabolic Process Insulin Secretion Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Drug Response To Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Negative Regulation Of Membrane Potential Response To Glucocorticoid Response To Interleukin-1 Response To Interleukin-4 Cellular Response To Norepinephrine Stimulus Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 20062062) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)	C-reactive protein ( 22939635) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		4 interactors: IL1A IL1B IL1RAP IL1RN	4 interactors: IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		7850	3557
HPRD ID		00995	00978
Ensembl ID		ENSG00000115590	ENSG00000136689
Uniprot IDs		P27930	P18510
PDB IDs		3O4O	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?		Fever Generation Heat Generation Temperature Homeostasis Acute-phase Response Inflammatory Response Acute Inflammatory Response Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Cytokine Ectopic Germ Cell Programmed Cell Death Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Interleukin-2 Biosynthetic Process Multicellular Organismal Homeostasis Regulation Of Interleukin-2 Biosynthetic Process Immune Response Positive Regulation Vascular Endothelial Growth Factor Production Defense Response Positive Regulation Of Interleukin-2 Production Developmental Programmed Cell Death Positive Regulation Of Mitotic Nuclear Division Regulation Of Vascular Endothelial Growth Factor Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Organic Substance Positive Regulation Of Cytokine Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of MAPK Cascade Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Secretion Extrinsic Apoptotic Signaling Pathway Regulation Of Cytokine Biosynthetic Process Response To Organic Substance Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Nuclear Division Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Positive Regulation Of Myosin Light Chain Kinase Activity Positive Regulation Of Cell Division Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Phosphorylation Cytokine Production Regulation Of Anion Transport Negative Regulation Of Apoptotic Process	Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of Chromosome Organization Telomere Formation Via Telomerase Protection From Non-homologous End Joining At Telomere DNA Replication Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Interleukin-1-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cytokine-mediated Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Positive Regulation Of DNA Biosynthetic Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process Regulation Of Double-strand Break Repair Protein Localization To Chromosome Response To Cytokine Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Response To Interleukin-1 Regulation Of Organelle Organization Chromosome Organization Regulation Of DNA Repair DNA Metabolic Process Positive Regulation Of DNA Replication Regulation Of DNA Recombination DNA Duplex Unwinding Response To Interleukin-1 DNA Geometric Change Immune Response Homeostatic Process
Tagcloud ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	asp299gly constant cosegregating differentially dysregulation endorsed explored fatigue genotyped investigating ischemic link nucleotide opposing polymorphisms poststroke psf remarkably rs4251961 rs4986790 rs4986791 snp snps stroke substitution substudy thr399ile tlr4 toll
Tagcloud (Difference) ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	asp299gly constant cosegregating differentially dysregulation endorsed explored fatigue genotyped investigating ischemic link nucleotide opposing polymorphisms poststroke psf remarkably rs4251961 rs4986790 rs4986791 snp snps stroke substitution substudy thr399ile tlr4 toll
Tagcloud (Intersection) ?