IL1B and LYN

Number of citations of the paper that reports this interaction (PMID 9230816)
1

Data Source:
BioGRID (pull down)

		IL1B	LYN
Gene Name		interleukin 1, beta	LYN proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule	Nucleus Cytoplasm Mitochondrial Intermembrane Space Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Mitochondrial Crista Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Mast Cell Granule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Domain Specific Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Enzyme Binding Ubiquitin Protein Ligase Binding Glycosphingolipid Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Fever Generation Positive Regulation Of Protein Phosphorylation Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Embryo Implantation Negative Regulation Of Cell Proliferation Response To Carbohydrate Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Glucose Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Neutrophil Chemotaxis Sequestering Of Triglyceride Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Secretion Interleukin-1 Beta Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Histone Phosphorylation Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Histone Acetylation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Myosin Light Chain Kinase Activity Cellular Response To Drug Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Adiponectin Secretion Monocyte Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation Inflammatory Response Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Central Nervous System Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Response To Organic Cyclic Compound Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Platelet Activation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Cytokine Secretion Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Peptide Hormone Stimulus Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways		Signaling by Interleukins Interleukin-1 processing Interleukin-1 signaling Cytokine Signaling in Immune system	Signaling by the B Cell Receptor (BCR) Platelet Adhesion to exposed collagen Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation Signaling by SCF-KIT EPHB-mediated forward signaling EPHA-mediated growth cone collapse Regulation of KIT signaling FCERI mediated NF-kB activation EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System CD28 co-stimulation CTLA4 inhibitory signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Growth hormone receptor signaling
Drugs		Minocycline Gallium nitrate Canakinumab Rilonacept
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		15 interactors: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 PRTN3 SP1	115 interactors: ACTB ADAM15 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119
Entrez ID		3553	4067
HPRD ID		00985	01301
Ensembl ID		ENSG00000125538	ENSG00000254087
Uniprot IDs		P01584	A8K379 P07948 Q6NUK7
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5I1B 6I1B 7I1B 9ILB	1W1F 1WA7 3A4O
Enriched GO Terms of Interacting Partners?		Regulation Of Inflammatory Response Cellular Response To Organic Substance Immune System Process Response To Organic Substance Immune Response Cytokine Production Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Stimulus Response To Stimulus Blood Coagulation Hemostasis Platelet Activation Innate Immune Response Response To Stress Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Platelet Degranulation Regulation Of Protein Metabolic Process Interleukin-1-mediated Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Interleukin-1 Beta Production Cell Activation Response To Wounding Cell Differentiation Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Cytokine Biosynthetic Process Regulation Of Signal Transduction Defense Response Response To Organonitrogen Compound Cytokine-mediated Signaling Pathway Cytokine Metabolic Process Cellular Response To Organonitrogen Compound Cellular Response To Acid Chemical Organ Development Response To Carbohydrate Regulation Of Signaling Central Nervous System Development Axonogenesis Peptidyl-tyrosine Autophosphorylation Response To Mechanical Stimulus Dendritic Cell Differentiation	Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Intracellular Signal Transduction Positive Regulation Of Immune System Process Defense Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Cell Activation Regulation Of Signaling Response To Organic Substance Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Locomotion Positive Regulation Of Protein Modification Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Blood Coagulation Positive Regulation Of Protein Phosphorylation Movement Of Cell Or Subcellular Component Hemostasis Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Platelet Activation
Tagcloud ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated
Tagcloud (Difference) ?		alteration anguillarum colonization fluorescently gfp gnotobiotic immunity immunomodulation indicative innate insights labeled larvae monitored mpx mucus nfkb niche nongnotobiotic pathogen pathogens sheltered stealth tlr4 trait trf typical vibrio zebrafish	5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated
Tagcloud (Intersection) ?