IL1R2 and IL1RAP

Number of citations of the paper that reports this interaction (PMID 9862719)
18

Data Source:
HPRD (in vivo)

		IL1R2	IL1RAP
Gene Name		interleukin 1 receptor, type II	interleukin 1 receptor accessory protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding	Signal Transducer Activity Interleukin-1 Receptor Activity
	Biological Process	Immune Response Cytokine-mediated Signaling Pathway	Protein Complex Assembly Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 20062062) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)	Lung cancer ( 18385676) Waist circumference ( 20966902)
Protein-Protein Interactions		4 interactors: IL1A IL1B IL1RAP IL1RN	19 interactors: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCH8 MC4R MYD88 PIK3R1 PRKCI PRPF40A RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		7850	3556
HPRD ID		00995	04021
Ensembl ID		ENSG00000115590	ENSG00000196083
Uniprot IDs		P27930	A8K6K4 Q9NPH3
PDB IDs		3O4O	3O4O 4DEP
Enriched GO Terms of Interacting Partners?		Fever Generation Heat Generation Temperature Homeostasis Acute-phase Response Inflammatory Response Acute Inflammatory Response Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Cytokine Ectopic Germ Cell Programmed Cell Death Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Interleukin-2 Biosynthetic Process Multicellular Organismal Homeostasis Regulation Of Interleukin-2 Biosynthetic Process Immune Response Positive Regulation Vascular Endothelial Growth Factor Production Defense Response Positive Regulation Of Interleukin-2 Production Developmental Programmed Cell Death Positive Regulation Of Mitotic Nuclear Division Regulation Of Vascular Endothelial Growth Factor Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Organic Substance Positive Regulation Of Cytokine Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of MAPK Cascade Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Secretion Extrinsic Apoptotic Signaling Pathway Regulation Of Cytokine Biosynthetic Process Response To Organic Substance Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Nuclear Division Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Positive Regulation Of Myosin Light Chain Kinase Activity Positive Regulation Of Cell Division Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Phosphorylation Cytokine Production Regulation Of Anion Transport Negative Regulation Of Apoptotic Process	Response To Cytokine Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Immune System Process Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cytokine Production Defense Response Response To Interleukin-1 Signaling Cell Communication Temperature Homeostasis Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of NF-kappaB Transcription Factor Activity Fever Generation Acute-phase Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Intracellular Signal Transduction Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Protein Transport Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Positive Regulation Of Immune Response Positive Regulation Of Intracellular Protein Transport Cellular Response To Molecule Of Bacterial Origin Regulation Of Protein Import Into Nucleus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Regulation Of Chemokine Production Heat Generation Response To Stimulus
Tagcloud ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Difference) ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il2 il4 il6 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Intersection) ?		il8