KLHL17 and ACTC1

Number of citations of the paper that reports this interaction (PMID 12063253)
14

Data Source:
HPRD (in vivo)

		KLHL17	ACTC1
Gene Name		kelch-like family member 17	actin, alpha, cardiac muscle 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Postsynaptic Density Actin Cytoskeleton Cell Junction Dendrite Cytoplasm Neuronal Cell Body Postsynaptic Membrane	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	POZ Domain Binding Protein Complex Scaffold Actin Filament Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Brain Development Protein Ubiquitination Actin Cytoskeleton Organization	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		1 interactors: ACTC1	35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1
Entrez ID		339451	70
HPRD ID		13926	00015
Ensembl ID		ENSG00000187961	ENSG00000159251
Uniprot IDs		Q6TDP4	B3KPP5 P68032
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Cardiac Myofibril Assembly Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Cardiac Muscle Contraction Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Cell Development Muscle Organ Morphogenesis Myofibril Assembly Striated Muscle Contraction Cardiac Muscle Cell Differentiation Actomyosin Structure Organization Cardiocyte Differentiation Response To Ethanol Striated Muscle Cell Development Muscle Cell Development Cardiac Muscle Tissue Development Muscle Contraction Heart Morphogenesis Striated Muscle Cell Differentiation Muscle System Process Muscle Organ Development Actin Filament Organization Blood Circulation Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Organelle Assembly Muscle Structure Development Response To Drug Heart Development	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly
Tagcloud ?			accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?			accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?