HTR6 and GNAS

Number of citations of the paper that reports this interaction (PMID 11916537)
71

Data Source:
HPRD (in vitro)

		HTR6	GNAS
Gene Name		5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	GNAS complex locus
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Histamine Receptor Activity Serotonin Receptor Activity Protein Binding	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Serotonin Receptor Signaling Pathway Synaptic Transmission Learning Negative Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Negative Regulation Of Acetylcholine Secretion, Neurotransmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling Response To Estradiol Positive Regulation Of Dopamine Secretion Response To Drug Long-term Synaptic Potentiation	Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog
Drugs		Ziprasidone Olanzapine Clozapine Quetiapine Aripiprazole Dimethyltryptamine Iloperidone Sertindole Asenapine
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		4 interactors: COPS5 FYN GNAQ GNAS	31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		3362	2778
HPRD ID		03066	00761
Ensembl ID		ENSG00000158748	ENSG00000087460
Uniprot IDs		P50406	O95467 P63092 P84996 Q5JWF2
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Regulation Of Protein Localization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Post-embryonic Body Morphogenesis Post-embryonic Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Embryonic Limb Morphogenesis Regulation Of Cellular Localization Limb Morphogenesis Regulation Of Protein Localization To Nucleus Limb Development Exosomal Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cognition Regulation Of Phosphorus Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Homotypic Cell-cell Adhesion Regulation Of Cell Differentiation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cullin Deneddylation Neuron Remodeling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Protein Deneddylation Regulation Of Gene Expression Response To Platelet-derived Growth Factor Forebrain Development Response To Peptide Hormone Regulation Of Melanocyte Differentiation Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Positive Regulation Of CAMP-mediated Signaling Response To Peptide Response To Drug Maternal Behavior Adrenergic Receptor Signaling Pathway Secretion By Cell Single Organismal Cell-cell Adhesion	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Intersection) ?