DNAJB1 and DNAJC3

Number of citations of the paper that reports this interaction (PMID 9920933)
25

Data Source:
HPRD (in vitro, two hybrid)

		DNAJB1	DNAJC3
Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 1	DnaJ (Hsp40) homolog, subfamily C, member 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Vesicle Extracellular Vesicular Exosome
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	Protein Kinase Inhibitor Activity Chaperone Binding Misfolded Protein Binding
	Biological Process	Response To Unfolded Protein Positive Regulation Of ATPase Activity Cellular Response To Heat Chaperone Mediated Protein Folding Requiring Cofactor Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Defense Response To Virus
Pathways		HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Influenza Viral RNA Transcription and Replication IRE1alpha activates chaperones Influenza Infection Viral mRNA Translation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Influenza Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 ZFP36	6 interactors: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A PRKRIR TIRAP
Entrez ID		3337	5611
HPRD ID		05198	03114
Ensembl ID		ENSG00000132002	ENSG00000102580
Uniprot IDs		B4DX52 P25685 Q6FHS4	A8KA82 Q13217
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ	2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Response To External Stimulus Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Temperature Stimulus Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Protein Metabolic Process Response To Unfolded Protein Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Protein Refolding Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Response To Superoxide Response To Oxygen Radical Chemotaxis Regulation Of Cell Death Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Oxidative Stress Blood Coagulation Hemostasis Reactive Oxygen Species Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Differentiation Superoxide Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Cellular Component Organization	Response To Unfolded Protein Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Inclusion Body Assembly Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Inclusion Body Assembly Protein Refolding Response To Stress Response To Biotic Stimulus Regulation Of Cellular Response To Heat Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Response To Organic Substance Regulation Of Chemokine Production Cellular Response To Heat Positive Regulation Of Protein Binding Regulation Of Translational Initiation Negative Regulation Of Translation Regulation Of Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cytokine Production Cellular Response To Stress Cellular Response To Unfolded Protein Evasion Or Tolerance By Virus Of Host Immune Response Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Interaction With Host ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Heat Positive Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Proliferation Response To External Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Stimulus Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Hematopoietic Stem Cell Differentiation Response To Other Organism Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	atf4 attenuation bcl2 bip chop confirming db ddit3 ebp homologue hsp40 hspa5 immunoglobulin interpretation islet islets min6 oleate overproduction p58 palmitate pancreas secreting sections supply triggers virtually xbp1
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	atf4 attenuation bcl2 bip chop confirming db ddit3 ebp homologue hsp40 hspa5 immunoglobulin interpretation islet islets min6 oleate overproduction p58 palmitate pancreas secreting sections supply triggers virtually xbp1
Tagcloud (Intersection) ?