DNAJB1 and ANK2

Number of citations of the paper that reports this interaction (PMID 15075330)
10

Data Source:
HPRD (in vitro, in vivo)

		DNAJB1	ANK2
Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 1	ankyrin 2, neuronal
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	Intracellular Cytosol Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	Structural Constituent Of Cytoskeleton Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding ATPase Binding
	Biological Process	Response To Unfolded Protein Positive Regulation Of ATPase Activity Cellular Response To Heat Chaperone Mediated Protein Folding Requiring Cofactor Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Axon Guidance Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Protein Targeting To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Membrane Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity
Pathways		HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS			Blood trace element (Cu levels) ( 23720494) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		28 interactors: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 ZFP36	12 interactors: DNAJB1 EPB42 KIAA0368 L1CAM NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53
Entrez ID		3337	287
HPRD ID		05198	00110
Ensembl ID		ENSG00000132002	ENSG00000145362
Uniprot IDs		B4DX52 P25685 Q6FHS4	Q01484
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ	4D8O
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Response To External Stimulus Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Temperature Stimulus Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Protein Metabolic Process Response To Unfolded Protein Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Protein Refolding Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Response To Superoxide Response To Oxygen Radical Chemotaxis Regulation Of Cell Death Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Oxidative Stress Blood Coagulation Hemostasis Reactive Oxygen Species Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Differentiation Superoxide Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Cellular Component Organization	Regulation Of Cellular Component Organization Regulation Of Cell Growth Membrane Organization Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Morphogenesis Neurogenesis Anatomical Structure Development Regulation Of Intracellular Signal Transduction Axonogenesis Cell Morphogenesis Cell Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Component Assembly Cell Projection Organization Regulation Of Growth Developmental Process Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Morphogenesis System Development Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Size Regulation Of Axon Extension Neuron Projection Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Neuron Projection Development Axon Guidance Neuron Development Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Endomembrane System Organization Regulation Of Signal Transduction B Cell Differentiation Negative Regulation Of Helicase Activity Protein Localization To M-band Positive Regulation Of Cell Growth Regulation Of Cell Projection Organization Protein Import Into Nucleus Protein Localization Protein Metabolic Process Nuclear Import Neuron Differentiation
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
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