DNAJB1 and NRAS

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		DNAJB1	NRAS
Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 1	neuroblastoma RAS viral (v-ras) oncogene homolog
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	Golgi Membrane Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	GTP Binding Protein Complex Binding
	Biological Process	Response To Unfolded Protein Positive Regulation Of ATPase Activity Cellular Response To Heat Chaperone Mediated Protein Folding Requiring Cofactor Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	MAPK Cascade Activation Of MAPKK Activity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Skeletal Muscle Tissue Development Leukocyte Migration Striated Muscle Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 ZFP36	19 interactors: ACVR1 ARHGAP4 BCL2 DNAJB1 EEF1A1 PIK3CA PIK3CG PLCE1 RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RPS20 SHOC2 SMAD4 SMURF2 SRI
Entrez ID		3337	4893
HPRD ID		05198	01273
Ensembl ID		ENSG00000132002	ENSG00000213281
Uniprot IDs		B4DX52 P25685 Q6FHS4	P01111 Q5U091
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ	3CON
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Response To External Stimulus Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Temperature Stimulus Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Protein Metabolic Process Response To Unfolded Protein Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Protein Refolding Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Response To Superoxide Response To Oxygen Radical Chemotaxis Regulation Of Cell Death Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Oxidative Stress Blood Coagulation Hemostasis Reactive Oxygen Species Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Differentiation Superoxide Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Cellular Component Organization	Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Ras Protein Signal Transduction Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cardiovascular System Development Cellular Response To Organic Substance Regulation Of Growth Regulation Of Cell Growth Response To Organic Substance Endocardial Cell Differentiation Positive Regulation Of Hydrolase Activity Cell Activation Regulation Of Protein Phosphorylation Response To Wounding Cell Proliferation Cellular Metal Ion Homeostasis Positive Regulation Of GTPase Activity Platelet Activation Blood Coagulation Hemostasis Cellular Cation Homeostasis Regulation Of GTPase Activity Cellular Ion Homeostasis Metal Ion Homeostasis Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation BMP Signaling Pathway Stem Cell Development
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Intersection) ?