DNAJB1 and HSF1

Number of citations of the paper that reports this interaction (PMID 9499401)
118

Data Source:
HPRD (in vitro)

		DNAJB1	HSF1
Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 1	heat shock transcription factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Protein Complex Pronucleus
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Response To Unfolded Protein Positive Regulation Of ATPase Activity Cellular Response To Heat Chaperone Mediated Protein Folding Requiring Cofactor Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Placenta Development Transcription, DNA-templated Protein Phosphorylation Defense Response Female Meiotic Division Spermatogenesis Negative Regulation Of Cell Proliferation Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Heat Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Process Involved In Female Pregnancy Regulation Of Spindle Checkpoint Regulation Of Cellular Response To Heat
Pathways		HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	HSF1 activation HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 ZFP36	47 interactors: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PLK1 PPID PRKDC PTGES3 RALBP1 REPS1 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE
Entrez ID		3337	3297
HPRD ID		05198	00778
Ensembl ID		ENSG00000132002	ENSG00000185122
Uniprot IDs		B4DX52 P25685 Q6FHS4	Q00613
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ	2LDU
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Response To External Stimulus Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Temperature Stimulus Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Protein Metabolic Process Response To Unfolded Protein Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Protein Refolding Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Response To Superoxide Response To Oxygen Radical Chemotaxis Regulation Of Cell Death Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Oxidative Stress Blood Coagulation Hemostasis Reactive Oxygen Species Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Differentiation Superoxide Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Cellular Component Organization	Regulation Of Cellular Response To Heat Cellular Response To Heat Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Heat Viral Process Response To Temperature Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Chaperone-mediated Protein Folding Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Gene Expression Innate Immune Response Cellular Protein Modification Process Regulation Of Cellular Process Peptidyl-serine Phosphorylation Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process
Tagcloud ?		chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression spleen stressed tnfalpha tnip1	atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan homologue hse hses hsp40 intron minimal mobility motifs primer race sequences supershift transcripts upstream
Tagcloud (Intersection) ?		heat shock