CFI and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		CFI	GLP1R
Gene Name		complement factor I	glucagon-like peptide 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Metal Ion Binding	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Proteolysis Receptor-mediated Endocytosis Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		3 interactors: C3 CFH GLP1R	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		3426	2740
HPRD ID		01955	00677
Ensembl ID		ENSG00000205403	ENSG00000112164
Uniprot IDs		A8K3L0 E7ETH0 G3XAM2 P05156	P43220
PDB IDs		2XRC	3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Hypersensitivity Regulation Of Protein Processing Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Apoptotic Cell Clearance Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process CAMP-mediated Signaling Response To Stress Positive Regulation Of Acute Inflammatory Response Innate Immune Response Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Immune Response Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Lipid Storage Positive Regulation Of Immune System Process Regulation Of Triglyceride Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Lyase Activity Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Positive Regulation Of Glucose Transport Response To Glucagon G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Regulation Of Lipid Storage Positive Regulation Of CAMP Biosynthetic Process Regulation Of Phagocytosis Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Immune Response Regulation Of Immune System Process Defense Response	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		agfi amos autonomic c30 cipn cipn20 concurrent confirmatory consistency convenience cronbach eortc fill gfi items korean loadings neuropathy neurotoxic nfi qlq reliability rmsr satisfactory spss subscale subscales validity version	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		agfi amos autonomic c30 cipn cipn20 concurrent confirmatory consistency convenience cronbach eortc fill gfi items korean loadings neuropathy neurotoxic nfi qlq reliability rmsr satisfactory spss subscale subscales validity version	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?