GP1BA and KNG1

Number of citations of the paper that reports this interaction (PMID 9269768)
7

Data Source:
HPRD (in vitro, in vivo)

		GP1BA	KNG1
Gene Name		glycoprotein Ib (platelet), alpha polypeptide	kininogen 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Thrombin Receptor Activity	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Thrombin Receptor Signaling Pathway	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Alpha-D-Mannose
Diseases
GWAS		Platelet counts ( 22139419 20139978)	Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		16 interactors: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP SELP TPST1 VWF YWHAZ	28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN
Entrez ID		2811	3827
HPRD ID		01976	01970
Ensembl ID		ENSG00000185245
Uniprot IDs		E7ES66	P01042
PDB IDs			2WOK 4ASQ 4ASR 4ECB 4ECC
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Intrinsic Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Platelet Activation Protein Activation Cascade Regulation Of Blood Coagulation Cell Activation Response To Stress Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Inflammatory Response Regulation Of Fibrinolysis Platelet Degranulation Defense Response Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Response To Stimulus Exocytosis Positive Regulation Of Fibrinolysis Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Secretion By Cell MRNA Transcription From RNA Polymerase II Promoter MRNA Transcription Secretion Negative Regulation Of Platelet Activation Cell Adhesion Regulation Of Ion Homeostasis Cellular Extravasation Fibrinolysis Cytosolic Calcium Ion Homeostasis Leukocyte Migration Positive Regulation Of Intracellular Transport Protein Processing Cellular Localization Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Acute Inflammatory Response Positive Regulation Of Transport Establishment Of Localization In Cell Threonylcarbamoyladenosine Biosynthetic Process	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 justifies mucocutaneous multiplexed ndufs1 pdha1 pemphigus pkp3 pmp22 slc36a4 sod2	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Difference) ?		acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 justifies mucocutaneous multiplexed ndufs1 pdha1 pemphigus pkp3 pmp22 slc36a4 sod2	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Intersection) ?