GNAZ and RGS10

Number of citations of the paper that reports this interaction (PMID 8774883)
59

Data Source:
HPRD (in vitro, in vivo)

		GNAZ	RGS10
Gene Name		guanine nucleotide binding protein (G protein), alpha z polypeptide	regulator of G-protein signaling 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Neuronal Cell Body Dendritic Spine Axon Terminus
	Molecular Function	GTPase Activity Signal Transducer Activity Receptor Signaling Protein Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding	GTPase Activator Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction	Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Signaling by GPCR GPCR downstream signaling PLC beta mediated events G alpha (s) signalling events G-protein activation Opioid Signalling G alpha (z) signalling events G alpha (i) signalling events G-protein mediated events	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		15 interactors: ADORA1 APP DRD2 DRD5 EYA1 EYA2 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	9 interactors: ADRB2 APP CALM1 GNAI1 GNAI3 GNAO1 GNAZ GNRHR PRKACA
Entrez ID		2781	6001
HPRD ID		00746	04172
Ensembl ID		ENSG00000128266	ENSG00000148908
Uniprot IDs		P19086 Q8IY73 Q8N652	O43665
PDB IDs			2DLR 2I59 2IHB
Enriched GO Terms of Interacting Partners?		Termination Of Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Blood Pressure Regulation Of Metabolic Process Histone Dephosphorylation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Associative Learning Response To Abiotic Stimulus Cognition Signaling Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission, Dopaminergic Neurological System Process Cell Communication Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Locomotory Behavior Apoptotic Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Receptor Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dephosphorylation Regulation Of GTPase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Circadian Rhythm Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Renal Sodium Excretion Regulation Of Cellular Process Learning Regulation Of Anion Transport Regulation Of Excretion	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Adenylate Cyclase Activity Platelet Activation Regulation Of Cyclase Activity Cell Surface Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Activation Of Adenylate Cyclase Activity Blood Coagulation Hemostasis Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Regulation Of Body Fluid Levels Wound Healing Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Signal Transduction Positive Regulation Of CAMP Metabolic Process Cell Activation Response To Wounding Signaling Cell Communication Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Organonitrogen Compound Cellular Response To Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Protein Binding Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Calcium Ion Transport Synaptic Transmission Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of CAMP Biosynthetic Process Regulation Of Ion Transport Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Metabolic Process Regulation Of Catalytic Activity Response To Stimulus Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Negative Regulation Of Nucleotide Metabolic Process
Tagcloud ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs12 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Difference) ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs12 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Intersection) ?