GNAZ and DRD5

Number of citations of the paper that reports this interaction (PMID 9603210)
14

Data Source:
HPRD (in vivo, in vitro)

		GNAZ	DRD5
Gene Name		guanine nucleotide binding protein (G protein), alpha z polypeptide	dopamine receptor D5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Receptor Signaling Protein Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Dopamine Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Associative Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus Reactive Oxygen Species Metabolic Process
Pathways		Signaling by GPCR GPCR downstream signaling PLC beta mediated events G alpha (s) signalling events G-protein activation Opioid Signalling G alpha (z) signalling events G alpha (i) signalling events G-protein mediated events	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Pramipexole Lisuride Apomorphine Fenoldopam Dopamine Carphenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		15 interactors: ADORA1 APP DRD2 DRD5 EYA1 EYA2 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	5 interactors: GABRG2 GNA12 GNA13 GNAZ NCS1
Entrez ID		2781	1816
HPRD ID		00746	00542
Ensembl ID		ENSG00000128266	ENSG00000169676
Uniprot IDs		P19086 Q8IY73 Q8N652	P21918
PDB IDs
Enriched GO Terms of Interacting Partners?		Termination Of Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Blood Pressure Regulation Of Metabolic Process Histone Dephosphorylation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Associative Learning Response To Abiotic Stimulus Cognition Signaling Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission, Dopaminergic Neurological System Process Cell Communication Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Locomotory Behavior Apoptotic Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Receptor Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dephosphorylation Regulation Of GTPase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Circadian Rhythm Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Renal Sodium Excretion Regulation Of Cellular Process Learning Regulation Of Anion Transport Regulation Of Excretion	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Shape Signal Transduction Platelet Activation Signaling Ras Protein Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Histamine Blood Coagulation Hemostasis Activation Of Phospholipase D Activity Regulation Of Cell Morphogenesis Cellular Response To Ammonium Ion In Utero Embryonic Development Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Gamma-aminobutyric Acid Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Fibroblast Migration Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Response To Wounding Chordate Embryonic Development Patterning Of Blood Vessels Embryo Development Ending In Birth Or Egg Hatching Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Developmental Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of Exocytosis Neuron-neuron Synaptic Transmission Embryonic Digit Morphogenesis Positive Regulation Of Phospholipase Activity
Tagcloud ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal
Tagcloud (Difference) ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	2j allen atlas b6 bc023892 btg3 bves edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting ptprn publicly punch rcn1 ucn westphal
Tagcloud (Intersection) ?