GNAZ and EYA1

Number of citations of the paper that reports this interaction (PMID 11950062)
10

Data Source:
HPRD (in vitro, two hybrid)

		GNAZ	EYA1
Gene Name		guanine nucleotide binding protein (G protein), alpha z polypeptide	EYA transcriptional coactivator and phosphatase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	GTPase Activity Signal Transducer Activity Receptor Signaling Protein Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding	RNA Binding Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction	Establishment Of Mitotic Spindle Orientation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Double-strand Break Repair Transcription, DNA-templated Pattern Specification Process Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Striated Muscle Tissue Development Histone Dephosphorylation Protein Sumoylation Cellular Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Peptidyl-tyrosine Dephosphorylation Aorta Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Pharyngeal System Development Lung Epithelial Cell Differentiation Otic Vesicle Morphogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by GPCR GPCR downstream signaling PLC beta mediated events G alpha (s) signalling events G-protein activation Opioid Signalling G alpha (z) signalling events G alpha (i) signalling events G-protein mediated events
Drugs
Diseases
GWAS		Height ( 18391951)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Sleepiness ( 17903308)
Protein-Protein Interactions		15 interactors: ADORA1 APP DRD2 DRD5 EYA1 EYA2 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	7 interactors: DACH1 GNAI2 GNAZ GSK3B SIX1 SIX2 SIX3
Entrez ID		2781	2138
HPRD ID		00746	03388
Ensembl ID		ENSG00000128266	ENSG00000104313
Uniprot IDs		P19086 Q8IY73 Q8N652	A6NCB9 Q99502
PDB IDs
Enriched GO Terms of Interacting Partners?		Termination Of Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Blood Pressure Regulation Of Metabolic Process Histone Dephosphorylation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Associative Learning Response To Abiotic Stimulus Cognition Signaling Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission, Dopaminergic Neurological System Process Cell Communication Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Locomotory Behavior Apoptotic Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Receptor Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dephosphorylation Regulation Of GTPase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Circadian Rhythm Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Renal Sodium Excretion Regulation Of Cellular Process Learning Regulation Of Anion Transport Regulation Of Excretion	Protein Localization To Organelle Negative Regulation Of Biosynthetic Process Protein Localization To Nucleus Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Cell Proliferation Mesenchyme Development Middle Ear Morphogenesis Cell Proliferation Nucleocytoplasmic Transport Nuclear Transport Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Commitment Cell Motility Stem Cell Differentiation Embryonic Organ Morphogenesis Developmental Induction Negative Regulation Of Cellular Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Locomotion Nephron Morphogenesis Positive Regulation Of Cellular Metabolic Process Pattern Specification Process Embryonic Organ Development Positive Regulation Of Transcription, DNA-templated Neuroblast Migration Mesenchymal Stem Cell Proliferation Cellular Protein Localization Cell Fate Specification Epithelial Cell Differentiation Kidney Morphogenesis Regulation Of Neuron Differentiation Metanephros Development Movement Of Cell Or Subcellular Component Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Stem Cell Proliferation Axis Specification Sensory Organ Development Positive Regulation Of Gene Expression Protein Import Into Nucleus Nuclear Import Ear Morphogenesis Regulation Of Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development
Tagcloud ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4
Tagcloud (Difference) ?		adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4
Tagcloud (Intersection) ?