GNAI2 and RGS5

Number of citations of the paper that reports this interaction (PMID 9079700)
22

Data Source:
HPRD (in vitro)

		GNAI2	RGS5
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	regulator of G-protein signaling 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	GTPase Activator Activity
	Biological Process	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport	Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	6 interactors: ADRB2 APP GNAI2 GNAI3 GNAO1 GNAQ
Entrez ID		2771	8490
HPRD ID		00764	04471
Ensembl ID		ENSG00000114353	ENSG00000143248
Uniprot IDs		B3KP24 B3KX51 P04899	O15539
PDB IDs			2CRP
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of Catalytic Activity Regulation Of CAMP Metabolic Process Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Neuron Remodeling Regulation Of Body Fluid Levels Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Wound Healing Positive Regulation Of Catalytic Activity Cell Activation Response To Stress Response To Wounding Negative Regulation Of Adenylate Cyclase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Lyase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of CAMP Biosynthetic Process Neuron Maturation Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Regulation Of Protein Phosphorylation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Signal Transduction Forebrain Development Regulation Of Phosphorylation Signaling Cell Communication Regulation Of Multicellular Organism Growth Behavior Positive Regulation Of Metabolic Process Regulation Of Ion Transport Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Protein Binding Cell Maturation Regulation Of Cellular Protein Metabolic Process Brain Development
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	allergen asm asthma asthmatic attributable bronchial bundles carbachol challenged contractile contraction copious gpcr gpcrs histamine hyperplastic hypertrophic mobilization mucus myocyte nonrespiratory obstruction paradoxically postmortem postreceptor procontractile shortening slices thrombin
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	allergen asm asthma asthmatic attributable bronchial bundles carbachol challenged contractile contraction copious gpcr gpcrs histamine hyperplastic hypertrophic mobilization mucus myocyte nonrespiratory obstruction paradoxically postmortem postreceptor procontractile shortening slices thrombin
Tagcloud (Intersection) ?