GNAI2 and LHB

Number of citations of the paper that reports this interaction (PMID 8663226)
11

Data Source:
HPRD (in vitro)

		GNAI2	LHB
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	luteinizing hormone beta polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Receptor Binding Hormone Activity
	Biological Process	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport	Progesterone Biosynthetic Process Signal Transduction Cell-cell Signaling Male Gonad Development Peptide Hormone Processing Cellular Protein Metabolic Process
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Androgen biosynthesis Metabolism of steroid hormones and vitamin D Peptide hormone metabolism GPCR downstream signaling Glycoprotein hormones Peptide hormone biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	4 interactors: CGA GNAI2 GNAS LHCGR
Entrez ID		2771	3972
HPRD ID		00764	01072
Ensembl ID		ENSG00000114353	ENSG00000104826
Uniprot IDs		B3KP24 B3KX51 P04899	P01229
PDB IDs			1M92
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity	Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP-mediated Signaling Regulation Of CAMP-mediated Signaling Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Post-embryonic Body Morphogenesis Platelet Activation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Cognition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Regulation Of Inositol Trisphosphate Biosynthetic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process Blood Coagulation Hemostasis Regulation Of Nitrogen Compound Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Adrenergic Receptor Signaling Pathway Hair Follicle Placode Formation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Signaling Regulation Of Body Fluid Levels Negative Regulation Of Multicellular Organism Growth Cellular Response To Hormone Stimulus Cell Communication Negative Regulation Of Adenylate Cyclase Activity
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish
Tagcloud (Intersection) ?