GNAI2 and C5AR1

Number of citations of the paper that reports this interaction (PMID 7962171)
2

Data Source:
HPRD (in vitro)

		GNAI2	C5AR1
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	complement component 5a receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Apical Part Of Cell
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Complement Component C5a Binding Complement Component C5a Receptor Activity C5a Anaphylatoxin Receptor Activity
	Biological Process	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport	Activation Of MAPK Activity Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Cell Proliferation In Hindbrain Neutrophil Chemotaxis Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	7 interactors: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS
Entrez ID		2771	728
HPRD ID		00764	00224
Ensembl ID		ENSG00000114353	ENSG00000197405
Uniprot IDs		B3KP24 B3KX51 P04899	P21730
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity	Positive Regulation Of MAPK Cascade Negative Regulation Of Interleukin-6 Production Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To External Stimulus Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Immune System Process Regulation Of Interleukin-6 Production Blood Coagulation Hemostasis Positive Regulation Of ERK1 And ERK2 Cascade G-protein Coupled Receptor Internalization Positive Regulation Of Signal Transduction Regulation Of Cytokine Production Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Immune System Process Regulation Of Phosphorylation Positive Regulation Of Receptor Internalization Regulation Of Body Fluid Levels Cell Chemotaxis Wound Healing Chemotaxis Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Migration Regulation Of Phosphorus Metabolic Process Platelet Activation Cell Activation Negative Regulation Of Cytokine Production Response To Wounding Negative Regulation Of Chemotaxis Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Endopeptidase Activity Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Peptidase Activity Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Regulation Of Immune Response Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Stress Receptor Internalization Positive Regulation Of Protein Modification Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Phosphorylation
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?