GNAI2 and FPR1

Number of citations of the paper that reports this interaction (PMID 8663057)
4

Data Source:
HPRD (in vivo)

		GNAI2	FPR1
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	formyl peptide receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome	Endosome Plasma Membrane Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Receptor Activity N-formyl Peptide Receptor Activity Protein Binding RAGE Receptor Binding
	Biological Process	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formyl peptide receptors bind formyl peptides and many other ligands
Drugs			Nedocromil
Diseases
GWAS
Protein-Protein Interactions		64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	5 interactors: ACTG1 ADRBK1 ANXA1 GNAI2 SAA1
Entrez ID		2771	2357
HPRD ID		00764	00646
Ensembl ID		ENSG00000114353
Uniprot IDs		B3KP24 B3KX51 P04899	P21462
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity	G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell Activation Platelet Activation Defense Response Blood Coagulation Hemostasis Response To Stress Regulation Of Phospholipase Activity Regulation Of Body Fluid Levels Wound Healing Regulation Of Secretion Endocytosis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Neutrophil Clearance Response To Wounding Positive Regulation Of Transport Regulation Of Cytokine Secretion Immune System Process Innate Immune Response DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Negative Regulation Of Phospholipase A2 Activity Regulation Of Cellular Localization Negative Regulation Of Interleukin-8 Secretion Prolactin Secretion Positive Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Phospholipase Activity Cell Surface Receptor Signaling Pathway Immune Response Negative Regulation Of Striated Muscle Contraction Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Stimulus Homeostatic Process Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Tachykinin Receptor Signaling Pathway Vesicle-mediated Transport Positive Regulation Of Myeloid Cell Apoptotic Process Receptor-mediated Endocytosis Regulation Of Phospholipase A2 Activity Positive Regulation Of Catecholamine Secretion Movement Of Cell Or Subcellular Component DNA Strand Renaturation Arachidonic Acid Secretion Regulation Of Protein Secretion Positive Regulation Of Fatty Acid Biosynthetic Process Adenosine Receptor Signaling Pathway Negative Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Secretion Inflammatory Response
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	amplified c5a c5ar chromosomes complement contained digestion electrophoresis filters formylpeptides fpr2 fprl2 fragment homologue hybridized il8ra il8rb kb kilobase library lie linkage mapped nylon probes pulsed restriction separated translated
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	amplified c5a c5ar chromosomes complement contained digestion electrophoresis filters formylpeptides fpr2 fprl2 fragment homologue hybridized il8ra il8rb kb kilobase library lie linkage mapped nylon probes pulsed restriction separated translated
Tagcloud (Intersection) ?