GNAI2 and LHCGR

Number of citations of the paper that reports this interaction (PMID 10493819)
5

Data Source:
HPRD (in vivo)

		GNAI2	LHCGR
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	luteinizing hormone/choriogonadotropin receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Luteinizing Hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Male Gonad Development Male Genitalia Development Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Cognition Cellular Response To Gonadotropin Stimulus
Pathways		Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin
Diseases
GWAS			Polycystic ovary syndrome ( 22885925 21151128) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	11 interactors: ARRB2 CANX CGA CGB CHST9 GIPC1 GNAI2 GNAS LHB SLC9A3R1 TSHR
Entrez ID		2771	3973
HPRD ID		00764	01073
Ensembl ID		ENSG00000114353	ENSG00000138039
Uniprot IDs		B3KP24 B3KX51 P04899	P22888
PDB IDs			1LUT 1XUL
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity	Cell-cell Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Processing Hormone Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Metabolic Process Signal Transduction Platelet Activation Dopamine Receptor Signaling Pathway Secretion Positive Regulation Of Signal Transduction Protein Processing Cell Activation Cellular Amide Metabolic Process Hormone Biosynthetic Process Cellular Response To Stimulus Regulation Of Adenylate Cyclase Activity Regulation Of Synaptic Transmission Acid Secretion Positive Regulation Of Intracellular Signal Transduction Regulation Of Cyclase Activity Renal Phosphate Ion Absorption Post-embryonic Body Morphogenesis Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Renal System Process Negative Regulation Of Sodium:proton Antiporter Activity Thyroid-stimulating Hormone Signaling Pathway Glutathione Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Multicellular Organism Growth Regulation Of CAMP Metabolic Process Protein Localization Adult Locomotory Behavior Cell Surface Receptor Signaling Pathway Secretion By Cell Protein Secretion Regulation Of Protein Kinase B Signaling Response To Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Reproductive Process
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Intersection) ?