BMP10 and ACVR2B

Number of citations of the paper that reports this interaction (PMID 22718755)
11

Data Source:
BioGRID (pull down)

		BMP10	ACVR2B
Gene Name		bone morphogenetic protein 10	activin A receptor, type IIB
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding
	Biological Process	Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ACVR2A ACVR2B BMPR2 SERINC3	18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		27302	93
HPRD ID		09788	04106
Ensembl ID		ENSG00000163217	ENSG00000114739
Uniprot IDs		O95393	Q13705
PDB IDs			2H62 2QLU 4FAO
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Regulation Of Osteoblast Differentiation Mesoderm Development Lymphangiogenesis Lymph Vessel Morphogenesis Gastrulation Regulation Of Ossification Venous Blood Vessel Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Signal Transduction By Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Gastrulation With Mouth Forming Second Artery Development Skeletal System Development Endothelial Cell Differentiation Regulation Of BMP Signaling Pathway Embryonic Morphogenesis Endothelium Development Positive Regulation Of Protein Phosphorylation Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Retina Development In Camera-type Eye Regulation Of Signaling Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process
Tagcloud ?		activin alk1 antitumor bmp9 cohorts correlative dalantercept diuretic edema escalating evaluable fatigue formerly gross hemorrhage morphogenetic perforations pharmacodynamic pharmacodynamics pharmacokinetics proteinuria recistv1 refractory responded subcutaneously telangiectasia tolerability toxicities underway	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Difference) ?		activin alk1 antitumor bmp9 cohorts correlative dalantercept diuretic edema escalating evaluable fatigue formerly gross hemorrhage morphogenetic perforations pharmacodynamic pharmacodynamics pharmacokinetics proteinuria recistv1 refractory responded subcutaneously telangiectasia tolerability toxicities underway	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Intersection) ?