BMP10 and BMPR2

Number of citations of the paper that reports this interaction (PMID 22718755)
11

Data Source:
BioGRID (pull down)

		BMP10	BMPR2
Gene Name		bone morphogenetic protein 10	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Signaling by BMP
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		4 interactors: ACVR2A ACVR2B BMPR2 SERINC3	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		27302	659
HPRD ID		09788	02880
Ensembl ID		ENSG00000163217	ENSG00000204217
Uniprot IDs		O95393	Q13873
PDB IDs			2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Regulation Of Osteoblast Differentiation Mesoderm Development Lymphangiogenesis Lymph Vessel Morphogenesis Gastrulation Regulation Of Ossification Venous Blood Vessel Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Signal Transduction By Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Gastrulation With Mouth Forming Second Artery Development Skeletal System Development Endothelial Cell Differentiation Regulation Of BMP Signaling Pathway Embryonic Morphogenesis Endothelium Development Positive Regulation Of Protein Phosphorylation Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Retina Development In Camera-type Eye Regulation Of Signaling Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?		activin alk1 antitumor bmp9 cohorts correlative dalantercept diuretic edema escalating evaluable fatigue formerly gross hemorrhage morphogenetic perforations pharmacodynamic pharmacodynamics pharmacokinetics proteinuria recistv1 refractory responded subcutaneously telangiectasia tolerability toxicities underway	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?		activin alk1 antitumor bmp9 cohorts correlative dalantercept diuretic edema escalating evaluable fatigue formerly gross hemorrhage perforations pharmacodynamic pharmacodynamics pharmacokinetics proteinuria recistv1 refractory responded subcutaneously telangiectasia tolerability toxicities underway	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?		morphogenetic