ACVR2B and GDF5

Number of citations of the paper that reports this interaction (PMID 8702914)
38

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ACVR2B	GDF5
Gene Name		activin A receptor, type IIB	growth differentiation factor 5
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye	Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Growth Regulation Of Multicellular Organism Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Differentiation Cell Development Negative Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Height ( 20881960 23563607 18391950 18391951 18391952 20189936)
Protein-Protein Interactions		18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1	8 interactors: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1
Entrez ID		93	8200
HPRD ID		04106	03092
Ensembl ID		ENSG00000114739	ENSG00000125965
Uniprot IDs		Q13705	P43026
PDB IDs		2H62 2QLU 4FAO	1WAQ 2BHK 3EVS 3QB4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process	Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway Mesoderm Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Skeletal System Development Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Organ Development Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signaling Negative Regulation Of Chondrocyte Proliferation Organ Morphogenesis Cartilage Development Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Connective Tissue Development Embryonic Morphogenesis Protein Phosphorylation Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis System Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Mesoderm Formation Multicellular Organismal Development Lymphatic Endothelial Cell Differentiation Mesoderm Morphogenesis Endothelium Development Positive Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Protein Modification Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry
Tagcloud ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a	astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic
Tagcloud (Difference) ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a	astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic
Tagcloud (Intersection) ?