ACVR2B and ERBB2IP

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		ACVR2B	ERBB2IP
Gene Name		activin A receptor, type IIB	erbb2 interacting protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Basement Membrane Nucleus Nucleoplasm Cytoplasm Plasma Membrane Basal Plasma Membrane Cell Junction Hemidesmosome Nuclear Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding	ErbB-2 Class Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye	Protein Targeting Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Growth Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL	Signaling by ERBB2
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1	62 interactors: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 NOD2 NR2E1 PICK1 PKP4 RAF1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		93	55914
HPRD ID		04106	06090
Ensembl ID		ENSG00000114739	ENSG00000112851
Uniprot IDs		Q13705	B4DIP2 Q96RT1
PDB IDs		2H62 2QLU 4FAO	1MFG 1MFL 1N7T 2H3L 2QBW 3CH8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process	Regulation Of Signaling Response To Stimulus Response To Organic Substance Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Junction Assembly Regulation Of Cell Proliferation SMAD Protein Complex Assembly Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Signal Transduction Cellular Response To Organic Cyclic Compound Organ Development Anatomical Structure Morphogenesis Cellular Component Assembly Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Renal System Development Negative Regulation Of Signaling Regulation Of Cell Motility Gastrulation Cell-cell Signaling Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Locomotion Response To Wounding Urogenital System Development Regulation Of Cell Migration System Development Regulation Of Epithelial Cell Proliferation Adherens Junction Organization Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Difference) ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Intersection) ?