ACVR2B and SYNJ2BP

Number of citations of the paper that reports this interaction (PMID 11882656)
9

Data Source:
HPRD (in vitro, two hybrid)

		ACVR2B	SYNJ2BP
Gene Name		activin A receptor, type IIB	synaptojanin 2 binding protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Mitochondrion Cell Surface Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding	Protein C-terminus Binding Type II Activin Receptor Binding
	Biological Process	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye	Positive Regulation Of Receptor Internalization Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Intracellular Distribution Of Mitochondria Positive Regulation Of Protein Localization To Cell Surface
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1	10 interactors: ACTB ACVR2A ACVR2B APP LRP1 LRP2 LRP8 RALBP1 SYNJ2 USHBP1
Entrez ID		93	55333
HPRD ID		04106	15455
Ensembl ID		ENSG00000114739
Uniprot IDs		Q13705	P57105
PDB IDs		2H62 2QLU 4FAO	2ENO 2JIK 2JIN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process	Endocytosis Phototransduction, Visible Light Positive Regulation Of Activin Receptor Signaling Pathway Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Response To Light Stimulus Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Response To External Stimulus Response To Radiation Regulation Of Activin Receptor Signaling Pathway Detection Of Abiotic Stimulus Signal Transduction Lipid Metabolic Process Activin Receptor Signaling Pathway Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Signaling Vesicle-mediated Transport Cell Communication Steroid Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Brain Development System Development Head Development Mating Gastrulation With Mouth Forming Second Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Organ Development Cellular Response To Stimulus Receptor-mediated Endocytosis Artery Development Regulation Of Signaling Cellular Lipid Metabolic Process Central Nervous System Development Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Anatomical Structure Development Ammon Gyrus Development Beta-amyloid Clearance Regulation Of Protein Phosphorylation Transport Blood Coagulation
Tagcloud ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Difference) ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Intersection) ?