KLK13 and SERPINF2

Number of citations of the paper that reports this interaction (PMID 14687906)
2

Data Source:
HPRD (in vitro)

		KLK13	SERPINF2
Gene Name		kallikrein-related peptidase 13	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Hydrolase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Protein Processing	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs			Ocriplasmin
Diseases
GWAS			Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		3 interactors: A2M SERPINA1 SERPINF2	17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		26085	5345
HPRD ID		05693	02029
Ensembl ID			ENSG00000167711
Uniprot IDs		Q86VI7 Q86VI8 Q9UKR3	P08697
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Exocytosis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis Acute-phase Response Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Regulation Of Proteolysis Cell Activation Response To Wounding Acute Inflammatory Response Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Methanol Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Response To Triglyceride Response To Chromate Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Cellular Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Serine-type Peptidase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Plasminogen Activation Inflammatory Response Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Complement Activation Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin	Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process
Tagcloud ?		10ra 10rb a2m abolish alpha2 destructive details disrupt edge enrich enriching exploited favoring hampering hinders immuno kallikrein likewise macroglobulin matching missing modulatory neighbor network paths prism representation shed weaken
Tagcloud (Difference) ?		10ra 10rb a2m abolish alpha2 destructive details disrupt edge enrich enriching exploited favoring hampering hinders immuno kallikrein likewise macroglobulin matching missing modulatory neighbor network paths prism representation shed weaken
Tagcloud (Intersection) ?