GAA and NUMBL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GAA	NUMBL
Gene Name		glucosidase, alpha; acid	numb homolog (Drosophila)-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Alpha-1,4-glucosidase Activity Carbohydrate Binding Maltose Alpha-glucosidase Activity	Protein Binding
	Biological Process	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Glycogen Catabolic Process Sucrose Metabolic Process Glucose Metabolic Process Lysosome Organization Locomotory Behavior Tissue Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis
Pathways
Drugs		Acarbose Miglitol
Diseases
GWAS			Kawasaki disease ( 22446962)
Protein-Protein Interactions		5 interactors: EP300 HIVEP1 NCF1 NUMBL STAT2	23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG
Entrez ID		2548	9253
HPRD ID		06006	04931
Ensembl ID		ENSG00000171298
Uniprot IDs		P10253	Q9Y6R0
PDB IDs			3F0W
Enriched GO Terms of Interacting Partners?		Interaction With Symbiont Histone H2B Acetylation Innate Immune Response Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Neuroblast Division In Subventricular Zone Regulation Of Tubulin Deacetylation Respiratory Burst Involved In Defense Response Response To Yeast Cell Surface Receptor Signaling Pathway Immune Response Killing By Host Of Symbiont Cells Defense Response Hydrogen Peroxide Biosynthetic Process Positive Regulation By Host Of Viral Transcription N-terminal Protein Amino Acid Acetylation Respiratory Burst Forebrain Neuroblast Division Negative Regulation Of Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Superoxide Anion Generation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Neutrophil Mediated Immunity Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Lateral Ventricle Development Viral Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Killing Of Cells Of Other Organism Somatic Stem Cell Division Cellular Response To Cytokine Stimulus N-terminal Protein Amino Acid Modification Defense Response To Fungus Regulation Of Cellular Response To Heat Immune System Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukocyte Mediated Cytotoxicity Hydrogen Peroxide Metabolic Process Leukotriene Metabolic Process Biosynthetic Process Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Transcription, DNA-templated Response To Cytokine Response To Fungus Response To Other Organism Regulation Of Type I Interferon-mediated Signaling Pathway	Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		birds corrected correction deficient endocytic endocytosed endocytosis existed fibroblasts glucosidase glycogen hamster illustrate kd lasted lethal lysosomes maltase mammals man myoblasts nmol normalize normalized ovary pompe quail replacement subfractions	ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Difference) ?		birds correction deficient endocytic endocytosed endocytosis existed fibroblasts glucosidase glycogen hamster illustrate kd lasted lethal lysosomes maltase mammals man myoblasts nmol normalize normalized ovary pompe quail replacement subfractions	ablation abrogated accordingly defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Intersection) ?		corrected